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4-((2,6-DIMETHYLMORPHOLIN-4-YL)SULFONYL)ANILINE is a chemical compound that features a morpholine-based structure with a sulfonyl group attached to an aniline moiety. This unique arrangement of functional groups endows it with specific chemical properties, making it a versatile building block in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
4-((2,6-DIMETHYLMORPHOLIN-4-YL)SULFONYL)ANILINE is used as a key intermediate in the synthesis of sulfonamidebenzamides. These compounds are selective apoptotic CHOP pathway activators of the unfolded protein response, which can be utilized in the development of therapeutic agents targeting specific cellular pathways involved in diseases.
Application Reason:
The use of 4-((2,6-DIMETHYLMORPHOLIN-4-YL)SULFONYL)ANILINE in the preparation of sulfonamidebenzamides is driven by its ability to contribute to the activation of the CHOP pathway, which is a part of the unfolded protein response. This pathway plays a crucial role in maintaining cellular homeostasis and can be targeted for therapeutic intervention in various diseases, particularly those characterized by protein misfolding and aggregation.

750607-99-9

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750607-99-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 750607-99-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,0,6,0 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 750607-99:
(8*7)+(7*5)+(6*0)+(5*6)+(4*0)+(3*7)+(2*9)+(1*9)=169
169 % 10 = 9
So 750607-99-9 is a valid CAS Registry Number.

750607-99-9Downstream Products

750607-99-9Relevant academic research and scientific papers

Discovery of sulfonamidebenzamides as selective apoptotic CHOP pathway activators of the unfolded protein response

Flaherty, Daniel P.,Miller, Justin R.,Garshott, Danielle M.,Hedrick, Michael,Gosalia, Palak,Li, Yujie,Milewski, Monika,Sugarman, Eliot,Vasile, Stefan,Salaniwal, Sumeet,Su, Ying,Smith, Layton H.,Chung, Thomas D. Y.,Pinkerton, Anthony B.,Aub, Jeffrey,Callaghan, Michael U.,Golden, Jennifer E.,Fribley, Andrew M.,Kaufman, Randal J.

, p. 1278 - 1283 (2014)

Cellular proteins that fail to fold properly result in inactive or disfunctional proteins that can have toxic functions. The unfolded protein response (UPR) is a two-tiered cellular mechanism initiated by eukaryotic cells that have accumulated misfolded p

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