75066-94-3Relevant articles and documents
Palladium-Catalyzed Three Carbon Chain Extension Reactions with Acrolein Acetals. A Convenient Synthesis of Conjugated Dienals
Patel, Babu A.,Kim, Jin-Il I.,Bender, Diana D.,Kao, Lien-Chung,Heck, Richard F.
, p. 1061 - 1067 (2007/10/02)
A variety of vinylic halides has been found to react with acrolein or methacrolein acetals and amines with palladium catalysts to form 5-amino 3-enal acetals and/or dienal acetals.The reaction products yield 2,4-dienals on treatment with aqueous acids, in moderate to good yields.Crotonaldehyde dimethyl acetal also undergoes the reaction, but only in low yields. 3-Buten-2-one ethylene ketal reacted well under the same conditions, however, and Hofmann elimination and hydrolysis of the product amine gave (E,E)-3,5-heptadien-2-one in 90percent yield.