75085-66-4

Upstream product

• 75082-91-6 Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 109-78-4 3-Hydroxypropionitrile 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 69504-00-3 N⁶-Benzoyl-5'-O-(monomethoxytrityl)adenosine 
• 15074-54-1 2-chlorophenyl dichlorophosphate 
• 72351-28-1 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) 
• 69504-09-2 N⁶-Benzoyl-2'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 

Downstream Products

• 75082-92-7 Triaethylammonium-6-benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin-3'-(2-chlorphenyl)phosphat> 
• 75074-02-1 N⁶-Benzoyl-2'-O-(tert-butyldimethylsilyl)adenosin-3'-(o-chlorphenyl)(β-cyanethyl)phosphat 

Relevant academic research and scientific papers

Nucleotide. XV. Synthese und Eigenschaften von 2'-O-t-Butyldimethylsilyl-5'-O-monomethoxytritylribonucleosid-3'-phosphotriestern, Ausgangssubstanzen fuer Oligonucleotid-Synthesen

The syntheses of two types of fully blocked ribonucleoside 3'-phosphotriesters 6-14 have been achieved in excellent yields from 2'-O-t-butyldimethylsilyl-5'-O-monomethoxytrityl-ribonucleosides 1-5 by phosphorylation with 2-chloro- and 2,5-dichlorophenylph

Synthesis and properties of adenylate trimers A2′p5′A2′p5′A, A2′p5′A3′p5′A and A3′p5′A2′p5′A

Triadenylates with (2′-5′)(2′-5′) and mixed (2′-5′)(3′-5′) and (3′-5′)(2′-5′) linkages respectively were synthesized via the phosphotriester approach followed by deblocking of the fully protected intermediates. The isomeric trimers were characterized by NMR- and CD-spectra and show very similar hypochromicity effects.