75092-30-7

Usage

Uses

Used in Organic Synthesis:
4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is used as a building block in organic synthesis for the creation of other compounds with similar structural motifs. Its unique combination of functional groups allows for versatile reactions and the formation of a wide range of chemical products.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is utilized as a starting material or intermediate in the development of new drugs. Its specific chemical structure may contribute to the discovery of novel therapeutic agents with potential applications in treating various diseases and medical conditions.

InChI:InChI=1/C5H5IN2O2/c1-8-4(5(9)10)3(6)2-7-8/h2H,1H3,(H,9,10)

Upstream product

• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 1354705-42-2 ethyl 4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid 
• 6647-96-7 4-iodo-1,5-dimethyl-1H-pyrazole 

Downstream Products

• 79229-61-1 7-oxo-1-methyl-5-phenylpyrano<3,4-c>pyrazole 
• 93703-04-9 4-(2-Methoxy-phenylamino)-2-methyl-2H-pyrazole-3-carboxylic acid 
• 93703-00-5 1-methyl-4-[(4-methylphenyl)amino]-1H-pyrazole-5-carboxylic acid 
• 93703-01-6 4-(4-Chloro-phenylamino)-2-methyl-2H-pyrazole-3-carboxylic acid 
• 93703-05-0 1-methyl-4-(2-nitrophenylamino)pyrazole-5-carboxylic acid 
• 93702-99-9 2-Methyl-4-phenylamino-2H-pyrazole-3-carboxylic acid 
• 499791-82-1 4-[(4-fluorophenyl)amino]-1-methyl-1H-pyrazole-5-carboxylic acid 
• 499791-95-6 4-[(4-benzylphenyl)amino]-1-methyl-1H-pyrazole-5-carboxylic acid 
• 1620074-54-5 C₁₃H₁₄IN₃O₂ 
• 1354705-42-2 ethyl 4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid 

Relevant academic research and scientific papers

New approach to electrochemical iodination of arenes exemplified by the synthesis of 4-iodopyrazoles of different structures

The two-stage electrosynthesis of 4-iodosubstituted pyrazole derivatives was performed. At the first stage, KIO3 was obtained at the Ni anode under the undivided galvanostatic conditions of electrolysis of an aqueous alkaline solution of KI (or I2) at the Ni anode. At the second stage, pyrazole and its derivatives were iodinated in the heterophase (H2O-CHCl3 (CCl4)) medium by the KIO3-KI (or KIO3-I2) system in the presence of H2SO4. The yields of iodopyrazoles were 74-92%. The electrochemical iodination of anisole, 2-methylpyrazole, and thiophene was carried out to form 4-iodoanisole (88% yield), 4,5-diiodo-2-methylimidazole (54% yield), and a mixture of 2-iodothiophene (60% yield) and 2,5-diiodothiophene (4% yield).

LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.

Efficient iodination of structurally varying pyrazoles in heterophase medium

A synthesis of 4-iodo-substituted pyrazoles by iodination of pyrazole and its derivatives in the heterophase (H2O/CHCl3 (CCl 4)) medium with the system KI-KIO3 in the presence of H2SO4 additives was accomplished. The yields of 4-iodo-substituted pyrazoles in the iodination of pyrazole, 3,5- dimethylpyrazole, pyrazole-3(5)-carboxylic acid, 1-methylpyrazole-3-carboxylic acid, 1-methylpyrazole-5-carboxylic acid, 3-nitropyrazole, 1-methyl-3- nitropyrazole, 1-methylpyrazole, 1-ethylpyrazole, and 1-isopropylpyrazole were within 80-97%, whereas in the case of 3-nitropyrazole-5-carboxylic acid it was 32%.