7510-15-8

Usage

Uses

Used in Pharmaceutical Industry:
(5-methoxy-1-methyl-1H-indol-3-yl)acetic acid is used as a potential therapeutic agent for the treatment of mood disorders and depression. Its role as a serotonin derivative suggests it may help in modulating neurotransmission and alleviating symptoms associated with these conditions.
Used in Gastroenterology:
In the field of gastroenterology, (5-methoxy-1-methyl-1H-indol-3-yl)acetic acid is studied for its potential role in regulating gastrointestinal function. Its effects on gastrointestinal motility and secretion could be beneficial for treating various gastrointestinal disorders.
Used in Inflammation Management:
(5-methoxy-1-methyl-1H-indol-3-yl)acetic acid is also being investigated for its potential in managing inflammation. Given its structural relation to serotonin, it may have implications for conditions where inflammatory processes are involved, offering a new avenue for therapeutic intervention.
These applications highlight the compound's versatility and the need for further research to fully understand and harness its potential in medical and pharmaceutical fields.

Upstream product

• 23304-48-5 (5-methoxy-1H-indol-3-yl)acetic acid methyl ester 
• 3471-31-6 5-methoxy-1H-indole-3-acetic acid 

Downstream Products

• 1334298-37-1 N-(2-(5-methoxy-1-methyl-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Substituted Heteroaromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands

Substituted heteroaromatic carboxamide and urea compounds corresponding to formula (i) processes for the preparation thereof, pharmaceutical compositions containing these compounds and also a method of using these compounds in pharmaceutical compositions for treating or inhibiting pain and other conditions mediated at least in part via the vanilloid receptor 1.

SUBSTITUTED HETEROAROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted heteroaromatic carboxamide and urea derivatives of formula (I), to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.

Organocatalyzed enantioselective fluorocyclizations

Enantioenriched fluorinated heterocycles can be prepared through fluorocyclizations of prochiral indoles (see scheme; Ts=tosyl, Bn=benzyl, Boc=tert-butoxycarbonyl). More than twenty examples for this cascade fluorination-cyclization, which is catalyzed by cinchona alkaloids and employs N-fluorobenzenesulfonimide as the electrophilic fluorine source have been explored, and an unprecedented catalytic asymmetric difluorocyclization has also been identified.

Rates of decarboxylation of the radical cations of indol-3-ylacetic acids and comparison with indolizin-1-ylacetic acids

The radical cations of indol-3-ylacetic acid and derivatives were found to eliminate CO2 to yield skatolyl radicals with rates in the range ca. 102 to >105 s-1, strongly dependent on substitution. For the radica