75100-63-9

Upstream product

• 186581-53-3 diazomethane 
• 907161-77-7 (2Z,4Z)-3-Hydroxy-5-phenyl-penta-2,4-dienoic acid 
• 53063-63-1 5-hydroxy-3-oxo-5-phenyl-valeric acid methyl ester 

Relevant academic research and scientific papers

Synthesis of highly substituted 2-spiropiperidines

2-Spiropiperidines are a highly desirable, yet under represented structure in drug discovery. 2-Spiropiperidines were synthesised in either a two-pot or one-pot reaction. In the two-pot reaction, the addition of a Weiler dianion to N-Boc imines, followed by deprotection and in situ condensation with a cyclic ketone generated functionalised 2-spiropiperidines in good to excellent yields. In the one-pot reaction, the addition of Chan's diene to N-Boc imines under Maitland-Japp conditions, followed by the addition of sodium bicarbonate and a cyclic ketone formed functionalised 2-spiropiperidines in moderate to good yields.

α-Carboxylation reaction of carbonyl compounds with bromomagnesium ureide-carbon dioxide adducts

Bromomagnesium ureide-carbon dioxide adducts, models of the carboxylated biotin complex, undergo caboxylation of a variety of carbonyl compounds in good yield.