53063-63-1

Basic information

• Product Name: 5-hydroxy-3-oxo-5-phenyl-valeric acid methyl ester
• Synonyms: 5-hydroxy-3-oxo-5-phenyl-valeric acid methyl ester
• CAS NO: 53063-63-1
• Molecular Weight: 222.241
• Mol File: 53063-63-1.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 5-hydroxy-3-oxo-5-phenyl-valeric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-3-oxo-5-phenyl-valeric acid methyl ester(53063-63-1)
• EPA Substance Registry System: 5-hydroxy-3-oxo-5-phenyl-valeric acid methyl ester(53063-63-1)

Safety Data

• Hazardous Substances Data: 53063-63-1(Hazardous Substances Data)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 67-56-1 methanol 
• 100-52-7 benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 141-97-9 ethyl acetoacetate 
• 62269-44-7 methyl 3-trimethylsiloxybut-2-enoate 
• 74590-73-1 1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene 
• 848900-70-9 5-(2-Chloro-acetoxy)-3-oxo-5-phenyl-pentanoic acid methyl ester 
• 81114-98-9 Chan's diene 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 74590-73-1 1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene 

Downstream Products

• 848900-70-9 5-(2-Chloro-acetoxy)-3-oxo-5-phenyl-pentanoic acid methyl ester 
• 18458-71-4 cis-2,6-diphenyltetrahydro-4H-pyran-4-one 
• 18458-72-5 trans-2,6-diphenyltetrahydro-4H-pyran-4-one 
• 113331-86-5 (2ξ,4RS,6RS)-6-phenyltetrahydropyran-2,4-diol 
• 113331-86-5 (2ξ,4RS,6SR)-6-phenyltetrahydropyran-2,4-diol 
• 113331-90-1 (4RS,6SR)-4-acetoxy-6-phenylterahydropyran-2-one 
• 113331-90-1 (4RS,6RS)-4-acetoxy-6-phenylterahydropyran-2-one 
• 1314789-08-6 methyl 2-methyl-4-oxo-6-phenyl-5,6-dihydro pyran-3-carboxylate 
• 75100-63-9 3-hydroxy-5-phenyl-penta-2,4-dienoic acid methyl ester 

Relevant articles and documents

Diastereoselective Synthesis of Highly Substituted Tetrahydropyran-4-ones

(Matrix Presented) Aldol reactions of β-ketoesters with aldehydes followed by a tandem Knoevenagel condensation, with a further equivalent of aldehyde, and intramolecular Michael addition produces single diastereomers of highly substituted tetrahydropyran-4-ones.

Investigation of the mechanism for the preparation of 6-phenyl-2,4- dioxotetrahydropyrans by the potassium carbonate promoted condensation between acetoacetate esters and benzaldehyde

Treatment of benzaldehyde and an acetoacetate ester with potassium carbonate in an alcohol solvent proceeds via γ-C-alkylation rather than α-C-alkylation resulting in the formation of 6-phenyl-2,4- dioxotetrahydropyran. Based upon results from deuterium e

A short and convenient strategy for the synthesis of pyridazines via Diaza-Wittig reaction

A convenient and selective synthesis of 6-substituted-4-hydroxy-3- methoxycarbonyl pyridazines has been developed via a diaza-Wittig reaction. The desired products substituted at the C6 position can be obtained from readily available starting materials under mild conditions. This represents an attractive new method for the synthesis of pyridazine derivatives.

Synthesis of multifunctionalized building blocks via vinylogous addition of Chan's diene to carbonyl and carbonyl-related electrophiles, mediated by molecular iodine

The synthesis of multifunctionalized β-ketoesters has been achieved by using molecular iodine as a catalyst under very mild conditions. The vinylogous addition of Chan's diene 1 to carbonyl and carbonyl-related compounds (aldehydes, ketones, imines and acetals) occurred with high efficiencies and with complete γ-selectivity, giving a useful method for the synthesis of interesting libraries of different δ-functionalized β-ketoesters.