75101-98-3

Upstream product

• 904295-66-5 α,α-bis(trimethylsilyl)-N-tert-butylpentaldimine 
• 100-52-7 benzaldehyde 
• 110-62-3 pentanal 
• 105479-98-9 ethyl 2-(acetoxy(phenyl)methyl)acrylate 
• 49707-50-8 pentanal tert-butylimine 
• 850497-60-8 (2E)-3-phenyl-2-propylprop-2-en-1-ol 

Downstream Products

• 93475-40-2 2-propyl-3t-phenyl-acrylaldehyde-semicarbazone 
• 849796-14-1 (1E,3S)-1-phenyl-2-propylhexa-1,5-dien-3-ol 
• 850497-60-8 (2E)-3-phenyl-2-propylprop-2-en-1-ol 

Relevant academic research and scientific papers

Copper-Catalyzed Stereospecific Hydroboration of Internal Allylic Alcohols

An effective Cu-catalyzed stereospecific hydroboration of aliphatic and aromatic 1,1,2-trisubstituted internal allylic alcohols has been reported. This reaction proceeds via a silyl ether transient protection of allylic alcohols and subsequent stereospecific hydroboration. Followed by an oxidative workup, an array of acyclic, cyclic, and heterocyclic 1,3-diols was synthesized in good to excellent yields with good functional group tolerance and excellent diastereomeric ratios (> 20:1).

COMPOUNDS REDUCING MALODOUR PERCEPTION AND THE USE THEREOF

The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3,R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.

A general route to α-alkyl (E)-α,β-unsaturated aldehydes

Bis(trimethylsilyl)-tert-butylaldimines 3 react with aldehydes in the presence of zinc bromide at room temperature to give, after hydrolysis, the desired α-alkyl α,β-ethylenic aldehydes in good yield and with very high E stereoselectivity. The reaction was believed to proceed via the α-silyl β-siloxyimines 4.

Asymmetric allylboration of α,β-enals as a surrogate for the enantioselective synthesis of allylic amines and α-amino acids

(Chemical Equation Presented) Optically pure allylic amines have been synthesized from α,β-unsaturated aldehydes via allylboration with (-)-B-allyldiisopinocampheylborane, followed by Overman rearrangement. By incorporating crotyl and alkoxyallylboration, functionalization at δ-position was readily accomplished. By applying this methodology, the synthesis of several chiral α-amino acids has been achieved.

Tetraalkylammonium and 1,3-dialkylimidazolium salts with fluorinated anions as recoverable phase-transfer catalysts in solid base-promoted cross-aldol condensations

Tetraalkylammonium and 1,3-dialkylimidazolium tetrafluoroborates and hexafluorophosphates were employed for the first time as recoverable phase-transfer catalysts in multiphase reactions of CH-acids, in particular in solid base-pro-moted cross-aldol condensations. The catalysts retained their catalytic activity over several reaction cycles.

Aldol Condensation of Aromatic nd Heterocyclic Aldehydes with Alkanals in Heterophase Systems

The aldol condensation of aromatic and heterocyclic aldehydes with propionaldehyde and valeraldehyde was realized in the two-phase systems consisting of solid potassium hydroxide, benzene, and benzyltriethylammonium chloride or solid potassium hydroxide and DMFA.The three-substituted 2-alkyl-2-propenals were obtained with high selectivity and high yields.

PHOSPHONATES α-LITHIES AGENTS DE TRANSFERT FONCTIONNEL. PREPARATION D'ALDEHYDES α,β-INSATURES α-SUBSTITUES.

Condensation of α-lithioalkylphosphonates with ethoxymethyleneaniline leads to lithiated enaminoalkylphosphonates directly convertible on reaction with aldehydes into α,β-unsaturated α-substituted aldehydes.