75103-22-9Relevant academic research and scientific papers
Design and synthesis of selenazole-substituted ritonavir analogs
Qiao, Junfei,Zhao, Chuanfang,Liu, Jun,Du, Yuguo
, p. 2379 - 2381 (2018/06/25)
With the help of Surflex-Dock calculation, two ritonavir analogs in which one thioazole unit was replaced by selenazole have been designed and synthesized. The key selenazole structure was constructed from β-azido diselenide through a cascade diselenide cleavage/selenocarbonylation/Staudinger reduction/aza-Wittig reaction and a following MnO2 oxidation. The accordingly prepared compounds exhibited good anti-HIV-1 (IIIB) activities comparable to that of the original ritonavir, as well as the positive SI values.
