75103-73-0

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 29601-98-7 N-benzylhydroxylamine hydrochloride 

Downstream Products

• 75103-75-2 2-benzyl-isoxazolidine-3r,5t-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 75103-75-2 2-benzyl-isoxazolidine-3r,5c-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 75103-74-1 2-benzyl-5,5-dimethyl-isoxazolidine-3-carboxylic acid ethyl ester 
• 145653-34-5 (3R*,4R*,5R*)-2-benzyl-3,4-diethoxycarbonyl-5-trifluoromethylisoxazolidine 
• 145653-35-6 (3R*,4R*,5R*)-2-benzyl-3,4-diethoxycarbonyl-5-methyl-5-trifluoromethylisoxazolidine 
• 145653-35-6 (3R*,4S*,5S*)-2-benzyl-3,4-diethoxycarbonyl-5-methyl-5-trifluoromethylisoxazolidine 
• 145653-36-7 (3R*,4R*)-2-benzyl-3,4-diethoxycarbonyl-5,5-bis(trifluoromethyl)isoxazolidine 
• 145653-36-7 (3R*,4S*)-2-benzyl-3,4-diethoxycarbonyl-5,5-bis(trifluoromethyl)isoxazolidine 

Relevant academic research and scientific papers

A large-scale low-cost preparation of n-benzylhydroxylamine hydrochloride

A high-yielding, practical two-step procedure for the preparation of N-benzylhydroxylamine starting from dibenzylamine is described. As specified in the detailed protocol, the reaction can be conveniently carried out on a > 0.5 mol laboratory scale.

1,3-Dipolar cycloaddition of N-substituted dipolarophiles and nitrones: Highly efficient solvent-free reaction

(Chemical Equation Presented) New isoxazolidines were synthesized in good to excellent yields by 1,3-dipolar cycloaddition of N-vinylamide dipolarophiles and nitrones. Strikingly, solvent-free conditions gave high conversion and yields, shortened reaction time, and minimized degradation products. N-Vinyloxazolidin-2-one and its analogues used in these cycloaddition reactions were conveniently prepared in excellent yields by a modified version of Buchwald's one-step copper-catalyzed vinylation using vinyl bromide. From the adducts, a two-step access to various unsymmetric aspartate derivatives was also described.