75107-57-2 Usage
Uses
Used in Pharmaceutical Industry:
(S)-S-Benzoylcaptopril is used as an intermediate in the synthesis of Captopril-d3 for the development of orally active ACE inhibitors. These inhibitors are essential in the treatment of hypertension and other cardiovascular diseases, as they help regulate blood pressure and improve heart function.
Used in Research and Development:
(S)-S-Benzoylcaptopril is also utilized in research and development for the study of angiotensin-converting enzyme (ACE) and its role in various physiological processes. (S)-S-Benzoylcaptopril aids in understanding the mechanisms of action of ACE inhibitors and their potential applications in medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 75107-57-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,1,0 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 75107-57:
(7*7)+(6*5)+(5*1)+(4*0)+(3*7)+(2*5)+(1*7)=122
122 % 10 = 2
So 75107-57-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H19NO4S/c1-11(10-22-16(21)12-6-3-2-4-7-12)14(18)17-9-5-8-13(17)15(19)20/h2-4,6-7,11,13H,5,8-10H2,1H3,(H,19,20)/t11-,13+/m1/s1
75107-57-2Relevant academic research and scientific papers
Synthesis and characterization of captopril derivatives
Li, He-Ping,Zhang, Juan-Juan,Qin, Long,Zhao, Ming-Dong
, p. 621 - 629 (2013/07/27)
To develop more potential angiotensin converting enzyme (ACE) inhibitors, a series of captopril (Cap) derivatives were synthesized, including Cap-glycine methyl ester, Cap-l-alanine methyl ester, Cap-l-aspartic acid dimethyl ester, Cap-l-lysine methyl ester, Cap-O-acylisourea, acetyl captopril, and benzoyl captopril. The resulting products were characterized by IR and UV-visible spectroscopy and MS, which showed the desired products were successfully synthesized. This could serve as a guide for rational design of highly potent ACE inhibitors.
