75107-76-5Relevant academic research and scientific papers
Solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes: access to cyclopentenones and dihydropyranols
Feng, Jian,Kong, Lichun,Xue, Xiao-Song,Zhang, Fang,Zhang, Junhua,Zheng, Hanliang,Zhu, Gangguo,Zhu, Haiqian
, p. 11420 - 11426 (2021/09/07)
Divergent synthesis is a powerful strategy for the fast assembly of different molecular scaffolds from identical starting materials. We describe here a solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes with sulfonyl chlorides for the direct construction of highly functionalized cyclopentenones and dihydropyranols that widely exist in bioactive molecules and natural products. Density functional theory calculations suggest that a uniqueN,N-dimethylacetamide-assisted 1,2-hydrogen transfer of alkoxy radicals is responsible for the cyclopentenone formation, whereas a C-C cleavage accounts for the selective production of dihydropyranols in acetonitrile and water at 50 °C. Given the simple and mild reaction conditions, excellent functional group compatibility, forming up to four chemical bonds, and tunable selectivity, it may find wide applications in synthetic chemistry.
Diaryl-2-(5H)-furanones as Cox-2 inhibitors
-
, (2008/06/13)
The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
A DIRECT THREE-CARBON ANNELATION TO CYCLOPENTENONE DERIVATIVES
Prempree, P.,Siwapinyoyos T.,Thebtaranonth, C.,Thebtaranonth, Y.
, p. 1169 - 1172 (2007/10/02)
Cyclopentenone derivatives were prepared by three-carbon alkylation followed by cyclisation of the ester.
