75112-66-2Relevant academic research and scientific papers
Thermolysis of 2-azido-3-(R-anilino)-1,4-naphthoquinones. Nitrene insertion versus hydrogen abstraction
Cárdenas-Chaparro, Agobardo,Leyva, Elisa,Loredo-Carrillo, Silvia E.,Martínez-Richa, Antonio,Platz, Matthew S.
, (2020/03/03)
2-chloro-3-(R-anilino)-1,4-naphthoquinones react with sodium azide upon refluxing in DMF. The thermochemistry of 2-azido-3-(R-anilino)-1,4-naphthoquinone is strongly modified by the substituent on aniline. Having an strong electron-donor like O-R results
Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors
Xu, Kai,Xiao, Zhiyan,Tang, Yan Bo,Huang, Li,Chen, Chin-Ho,Ohkoshi, Emika,Lee, Kuo-Hsiung
supporting information; experimental part, p. 2772 - 2774 (2012/05/20)
Fourteen naphthoquinone derivatives (1-14) were designed based on a putative proteasome inhibitor PI-083. These compounds were synthesized and evaluated against A549, DU145, KB, and KBvin tumor cell lines. Six compounds (2, 4, 8, 9, 10, and 13) showed ant
Palladium-catalyzed amination of 2,3-dichloro-1,4-naphthoquinone with nitroarylamines
Wang, Xiao-Lei,Zheng, Xiu-Fang,Reiner, John
, p. 942 - 944 (2007/10/03)
A convenient one-step synthesis of 2-[(nitroaryl)amino]-3-chloro-1,4- naphthoquinones is reported. The direct amination of 2,3-dichloro-1,4- naphthoquinone with nitro-substituted aryl amines is catalyzed by PdCl 2(dppf)/dppf in the presence of
Direct nitration of 3-arylamino-2-chloro-1,4-naphthoquinones
Win, Thida,Yerushalmi, Sarit,Bittner, Shmuel
, p. 1631 - 1634 (2007/10/03)
A convenient two-step synthesis of mononitro and dinitro derivatives of the title compounds is reported. The Michael type addition of aromatic amines to 2,3-dichloro-1,4-naphthoquinone, is followed by mixed acids nitration to yield nitro aromatic quinones
Synthesis and Structure of Chlorine-Containing 2-Amino-1,4-naphthoquinone Derivatives
Litvin, B. L.,Gubrii, Z. V.,Shermolovich, Yu. G.,Novikov, V. P.
, p. 377 - 383 (2007/10/03)
Exhaustive chlorination of 2-amino-1,4-naphthoquinone derivatives yields 3,3-dichloro-2-imino-2,3-dihydro-1,4-naphthoquinones.
