75125-31-4

Upstream product

• 2216-92-4 N-phenylglycine ethyl ester 
• 541-41-3 chloroformic acid ethyl ester 
• 103-01-5 N-Phenylglycine 
• 7647-01-0 hydrogenchloride 
• 75125-32-5 N-ethoxycarbonyl-N-phenyl-glycine ; ammonium salt 
• 79-22-1 methyl chloroformate 

Downstream Products

• 571170-47-3 ethyl 2-((ethoxycarbonyl)(phenyl)amino)acetate 
• 861567-35-3 N-ethoxycarbonyl-N-phenyl-glycyl chloride 
• 861552-02-5 N-(N-ethoxycarbonyl-N-phenyl-glycyl)-glycine ethyl ester 
• 490-56-2 3-phenyl-oxazolidine-2,5-dione 
• 75125-33-6 [2-(1,3-Dicyclohexyl-ureido)-2-oxo-ethyl]-phenyl-carbamic acid ethyl ester 

Relevant academic research and scientific papers

Process and intermediates for β-lactam antibiotics

1-Benzyl (or substituted benzyl)-3β-[4(S)-aryloxazolidin-2-one-3-yl]-4β-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic β-lactam antibiotics.

7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof

7β-Acylamino-3-trifluoromethylsulfonyloxy-1-carba-3-cephem-4-carboxylic acid antibiotic compounds, esters and salts thereof, and the corresponding 7-amino and protected 7-amino 1-carbacephalosporins are provided. The 3-trifluoromethylsulfonyloxy-substituted 1-carbacephalosporins also are useful in a process for preparing 3-halo-1-carbacephalosporins which comprises reacting a 3-triflate ester with a lithium halide in an aprotic polar solvent.