75129-04-3Relevant academic research and scientific papers
Ultrasound-assisted one-pot synthesis of tetrahydropyrimidne derivatives through biginelli condensation: A catalyst free green chemistry approach
Patel, Ashish,Shah, Jinagna,Patel, Kesha,Patel, Krishna,Patel, Harit,Dobaria, Divyesh,Shah, Umang,Patel, Mehul,Chokshi, Avani,Patel, Samir,Parekh, Nikunj,Shah, Hirak,Patel, Harnisha,Bambharoliya, Tushar
, p. 749 - 756 (2021/09/30)
The aim of present work is one-pot catalyst free green synthesis of tetrahydropyrimidne derivatives through Biginelli condensation under ultrasonic irradiation. The chemical applications of ultrasound, sonochemistry , has become an exciting new field of research during the past decade as it can increase reactivities by nearly a million fold. Owing to the increasing use of Green technology approach, due to its various merits over Classical methodology and as a need for sustainable Chemistry, this reaction has received renewed interest for preparing tetrahydropyrimidine (THPM) through Biginelii condensation in an environmentally thoughtful manner with improved yields. The objective of the present study is focused on developing novel Ultrasound-Assisted catalyst free one-pot synthesis of tetrahydropyrimidne derivatives through Biginelli condensation We, herein describe a highly efficient catalyst free one-pot green synthesis of tetrahydropyrimidine derivatives using Biginelli protocol under ultrasonic irradiation at 50°C. All the products were characterized by comparing their physical and spectral data with those of authentic compounds reported in the literature. A green and efficient ultrasound-assisted one-pot synthesis method for tetrahydro-yrimidine derivatives have been developed through Biginelli condensation. The technique affords up to 99% yield in only 5–20 minutes under mild heating. Each synthesized compounds were fully characterized through spectral techniques viz. IR,1H NMR, and Mass Spectroscopy. A green and efficient ultrasound-assisted one-pot synthesis method for tetrahy-droyrimidine derivatives have been developed through Biginelli condensation. The present sonochemistry based green chemistry approach with no additional acid catalyst produces no waste, shows a significant enhancement in reaction rates under mild ultrasound irradiation in excellent yields and therefore represents a green and enviro-economic synthetic methodology for the Biginelli condensation in comparison to conventional heating/micro-wave irradiation.
Synthesis of Novel Substituted Tetrahydropyrimidine Derivatives and Evaluation of Their Pharmacological and Antimicrobial Activities
Mahmoud, Naglaa F. H.,Ghareeb, Eman A.
, p. 81 - 91 (2018/12/11)
Tetrahydropyrimidine derivative 1 was employed as intermediate compound, which in turn was allowed to react with different electrophilic and nucleophilic reagents to synthesize new polyfunctionalized series of substituted pyrimidine-2-thione derivatives. Structures of the newly synthesized compounds have been elucidated by spectroscopic data and elemental analyses. The pharmacological and antimicrobial activities of synthesized products have been evaluated as drug candidates.
Synthesis and antiviral activity of new substituted pyrimidine glycosides
Ramiz, Mahmoud M. M.,El-Sayed, Wael A.,Hagag, Ezzat,Abdel-Rahman, Adel A.-H.
experimental part, p. 1028 - 1038 (2011/11/29)
A number of N-substituted pyrimidine glycosides were synthesized by coupling reaction of the pyrimidine base with acetobromosugars followed by deprotection. The synthesized compounds were tested for their antiviral activity against Hepatitis B Virus (HBV). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high anti viral activities.
Synthesis of 2,4-Dioxo-,2-Oxo-4-thio-,4-Oxo-, and 4-Thioxo-pyrimidine-5-carbonitriles
Cuadrado, Francisco J.,Perez, Miguel A.,Soto, Jose L.
, p. 2447 - 2450 (2007/10/02)
Methyl N-methoxycarbonylimidates (1)-(4) cyclized readily with 2-cyanoacetamide (5) or 2-cyanoethanethioamide (6) to 2,4-dioxopyrimidine-5-carbonitriles (7)-(10) or 2-oxo-4-thioxopyrimidine-5-carbonitriles (11) and (12).In analogous reactions with alkyl N-acylimidates (15)-(19) 4-oxopyrimidine-5-carbonitriles (20)-(23) or 4-thioxopyrimidine-5-carbonitrile (24) were obtained.Representatives of 4-thioxopyrimidine-5-carbonitriles (11), (24) were methylated to 4-methylthiopyrimidine-5-carbonitriles (13) and (25) or cyclized with methyl chloroacetate to give methyl thienopyrimidine-6-carboxylates (14) and (26)
