75129-62-3Relevant academic research and scientific papers
Synthesis and antibacterial activity of a series 1-aryl-2-mercapto-5--1,3,4-triazoles, thiadiazoles and 2--3,4,5-trisubstituted pyrazoles
Nagrund, L. V. G.,Reddy, G. R. N.,Hariprasad, V.
, p. 499 - 502 (2007/10/03)
A series of new 1-aryl-2-mercapto-5--1,3,4-triazoles, 2-arylamino-5--1,3,4-thiadiazoles, p-acetamido(phenoxy)acetyl thio-semicarbazides and 2--3-amino-4-carboxamido-5-methylthiopyrazole have been prepared and evaluated for comparative antibacterial activity.The antibacterial activity of the target compounds and their relevant reference agent have been determined in vitro using serial 2-fold dilution technique on an assortment of Gram negative and Gram positive organisms.It has been observed that the in vitro antibacterial activity of cyclized 1,3,4-triazoles and 1,3,4-thiadiazoles are significantly greater than thiosemicarbazides.The derivatives 4b, 5b have better in vitro antibacterial activity.
