75143-77-0

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 89-98-5 2-chloro-benzaldehyde 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 123-54-6 acetylacetone 

Downstream Products

• 103806-27-5 2-acetyl-3-(2-chlorophenyl)-4-(3-methyl-4-nitroisoxazol-5-yl)butyric acid ethyl ester 
• 79510-71-7 5-(2-Chloro-phenyl)-3'-methyl-4'-nitro-3-phenyl-4,5-dihydro-[4,5']biisoxazolyl 
• 79510-58-0 3-[1-(2-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl]pentane-2,4-dione 
• 86461-84-9 5-[1,2-Dibromo-2-(2-chloro-phenyl)-ethyl]-3-methyl-4-nitro-isoxazole 
• 869586-75-4 4-(2-chlorophenyl)-5-(3-methyl-4-nitroisoxazol-5-yl)pentan-2-one 
• 1021951-89-2 (1R,2S)-1-(2-chlorophenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane-1,2-diol 
• 53558-05-7 5-(2-chloro-styryl)-3-methyl-isoxazol-4-ylamine 
• 1316316-21-8 C₂₉H₂₇ClN₄O₇ 
• 1242340-73-3 C₂₇H₂₁ClN₆O₇ 
• 1380544-35-3 5-(2-chlorophenethyl)-3-methyl-4-nitroisoxazole 
• 1459161-39-7 tert-butyl (2S)-2-((1R)-1-(2-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 704-96-1 trans-2-chlorocinnamic acid 
• 108175-93-5 C₂₄H₁₈Cl₂N₄O₆ 
• 1448590-06-4 C₂₄H₂₀ClN₂O₃P 

Relevant academic research and scientific papers

Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

An efficient solvent-free synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using solid nano-titania

Abstract: An efficient and solvent-free procedure for the synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using nano-titania as solid support and recyclable catalyst is presented. This method provides clean, simple, solvent-free and useful alternative to

Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam

Highly efficient asymmetric vinylogous 1,6-Michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl- isoxazoles and Michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25:1 dr and 96% ee).

Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides

A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially available materials. The title compounds 1 were also synthesized by a step-wise method and found to b

A fast and highly efficient protocol for synthesis of pyrrolo[2,3-d] isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles using task-specific ionic liquids as catalyst and green solvent

We report a mild, fast, highly efficient and eco-friendly protocol for the green synthesis of pyrrolo[2,3-d]isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles from nitro styrylisoxazoles in SnCl 2-ionic liquid by reductive

Multi-component synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N- oxides

A three component one-pot protocol was investigated for the synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N-oxides from commercially available materials.

Multicomponent synthesis of spiroisoxazolines

A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.

Michael additions on isoxazole derivatives under solvent-free conditions

Knoevenagel condensation of 3,5-dimethyl-4-nitro-isoxazole 1 with aromatic aldehydes in solid state in the presence of piperidine gives 3-methyl-4-nitro-5-styryl-isoxazoles 2 in excellent yields within few minutes. Michael addition of active methylene com

Chemistry of Heterocylces: Part VIII - Synthesis of Isoxazolylethylpyrazoles

The base-catalysed addition of acetylacetone to 3-methyl-4-nitro-5-styrylisoxazoles (II) leads to the Michael adducts 3-pentane-2,4-diones (III).These β-diketones (III) undergo cyclization with hydrazine sulphate and phenylhydrazine to furnish pyrazoles (IV) and N-phenylpyrazoles (V), respectively.