75143-79-2

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 104-87-0 4-methyl-benzaldehyde 
• 123-54-6 acetylacetone 
• 300-87-8 3,5-dimethyl-1,2-oxazole 

Downstream Products

• 103806-31-1 2-Acetyl-4-(3-methyl-4-nitro-isoxazol-5-yl)-3-p-tolyl-butyric acid ethyl ester 
• 86454-00-4 5-(1,2-Dibromo-2-p-tolyl-ethyl)-3-methyl-4-nitro-isoxazole 
• 79510-69-3 3'-Methyl-4'-nitro-3-phenyl-5-p-tolyl-4,5-dihydro-[4,5']biisoxazolyl 
• 79510-60-4 3-[2-(3-Methyl-4-nitro-isoxazol-5-yl)-1-p-tolyl-ethyl]-pentane-2,4-dione 
• 98239-38-4 5-[2-(3,5-Dimethyl-1H-pyrazol-4-yl)-2-p-tolyl-ethyl]-3-methyl-4-nitro-isoxazole 
• 98239-49-7 5-[2-(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)-2-p-tolyl-ethyl]-3-methyl-4-nitro-isoxazole 
• 78636-40-5 C₁₈H₁₉N₃O₄ 
• 117838-24-1 2-{1-[(Z)-Hydroxyimino]-ethyl}-4-(3-methyl-4-nitro-isoxazol-5-yl)-3-p-tolyl-butyric acid ethyl ester 
• 117838-19-4 7-Hydroxy-2-methyl-3-[2-(3-methyl-4-nitro-isoxazol-5-yl)-1-p-tolyl-ethyl]-chromen-4-one 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 905295-11-6 3-methyl-5-(2-p-tolyl-vinyl)-isoxazol-4-ylamine 
• 1262968-92-2 2-(3-methyl-4-nitro-isoxazol-5-yl)-1-p-tolylethanesulfonic acid 
• 1314231-03-2 5-(2-benzylsulfanyl-2-(4-methylphenyl)ethyl)-3-methyl-4-nitroisoxazole 
• 1355250-42-8 8,8'-(4-methylphenylmethylene)bis(3-methyl-5,7-di-phenyl-7,8-dihydro-6H-isoxazolo[4,5-b]azepine) 

Relevant academic research and scientific papers

Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

An efficient solvent-free synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using solid nano-titania

Abstract: An efficient and solvent-free procedure for the synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using nano-titania as solid support and recyclable catalyst is presented. This method provides clean, simple, solvent-free and useful alternative to

One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions

One-pot synthesis of highly functionalized tetrahydrothiophene (thiolane) derivatives conjugated with biologically useful isooxazole are reported via the Knoevenagel condensation followed by domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactio

Catalytic enantioselective addition of isocyanoacetate to 3-methyl-4-nitro-5-styrylisoxazoles under phase transfer catalysis conditions

The reaction between 3-methyl-4-nitro-5-styrylisoxazoles and ethyl isocyanoacetate proceeded under phase transfer catalysis to give enantioenriched monoadducts in high enantiomeric excess (up to 99% ee). The resulting adducts were subsequently cyclised to give 2,3-dihydropyrroles and substituted pyrrolidines in identical high ees and as a single diastereoisomer.

Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam

Highly efficient asymmetric vinylogous 1,6-Michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl- isoxazoles and Michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25:1 dr and 96% ee).

Studies on the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles

We have investigated the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles. This study revealed that the title compounds were optimal Michael acceptors toward thiols. A procedure was also established to prepare isoxazole-containing sul

Trifluoromethylation of aromatic isoxazoles: Regio- and diastereoselective route to 5-trifluoromethyl-2-isoxazolines

It all adds up: The activation of aromatic isoxazoles with a nitro group at the 4-position has enabled the first regio- and diastereoselective trifluoromethylation at the 5-position of isoxazoles by nucleophilic addition using Me3SiCF3 (see scheme; DMF=N,N′- dimethylformamide). The process was demonstrated with a broad range of 3,5-aromatic, heteroaromatic and aliphatic substrates.

A fast and highly efficient protocol for synthesis of pyrrolo[2,3-d] isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles using task-specific ionic liquids as catalyst and green solvent

We report a mild, fast, highly efficient and eco-friendly protocol for the green synthesis of pyrrolo[2,3-d]isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles from nitro styrylisoxazoles in SnCl 2-ionic liquid by reductive

Multi-component synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N- oxides

A three component one-pot protocol was investigated for the synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N-oxides from commercially available materials.

Michael additions on isoxazole derivatives under solvent-free conditions

Knoevenagel condensation of 3,5-dimethyl-4-nitro-isoxazole 1 with aromatic aldehydes in solid state in the presence of piperidine gives 3-methyl-4-nitro-5-styryl-isoxazoles 2 in excellent yields within few minutes. Michael addition of active methylene com