751436-48-3Relevant academic research and scientific papers
Azetadiene iron carbonyl compounds and their preparation and application
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Paragraph 0111-0113, (2022/01/20)
The present invention discloses the structure of two novel azerodiene iron carbonyl compounds having a structure shown in formula (1): (R = adamantyl, 1-naphthyl), formula (1). The present invention discloses a method for preparing these two compounds: fi
Discovery of tert-amine-based RORγt agonists
Qiu, Ruomeng,Yu, Mingcheng,Gong, Juwen,Tian, Jinlong,Huang, Yafei,Wang, Yonghui,Xie, Qiong
, (2021/07/26)
The nuclear receptor retinoic acid receptor-related orphan receptor gamma-t (RORγt) is a transcription factor regulating Th17 cell differentiation and proliferation from naive CD4+ T cells. Since Th17 cells have demonstrated the antitumor efficacy by eliciting remarkable activation of CD8+ T cells, RORγt agonists could be applied as potential small molecule therapeutics for cancer immunotherapy. Based on the previously reported RORγt agonist 1 and its resolved co-crystal structure, a series of new tertiary amines were designed, synthesized and biologically evaluated, yielding optimal moieties with improved chemical properties and biological responses. The combination of these optimal moieties resulted in identification of novel RORγt agonists such as 8b with further elevated RORγt agonism responses at a target-based level as well as in cell-based assays, which provided some structural knowledge for further optimization of RORγt agonists as small molecule therapeutics for cancer immunotherapy.
Tertiary amine derivative or salt thereof, preparation method and application thereof
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Paragraph 0185; 0188; 0189; 0190, (2019/01/24)
Belonging to the technical field of chemical medicine, the invention relates to a tertiary amine RORgamma t regulator, in particular to a new tertiary amine compound or salt thereof with RORgamma t inhibition or agonist activity shown as general formula I, a preparation method and a pharmaceutical composition thereof. The tertiary amine compound or a salt thereof provided by the invention can be used for preparation of drugs treating or preventing RORgamma t receptor related diseases.
Methyl-triflate-mediated dearylmethylation of: N -(arylmethyl)carboxamides via the retro-Mannich reaction induced by electrophilic dearomatization/rearomatization in an aqueous medium at room temperature
Peng, Hui,Ma, Jinhui,Luo, Wenkun,Zhang, Guangwen,Yin, Biaolin
, p. 2252 - 2256 (2019/05/17)
We have developed a protocol for the dearylmethylation of N-(arylmethyl)carboxamides under metal-free conditions in an aqueous medium at room temperature. This protocol involves methyl triflate-mediated successive C-C and C-N bond cleavages (retro-Mannich reaction) induced by electrophilic dearomatization/rearomatization. The dearomatization/rearomatization strategy can be expected to inspire the development of novel transformations based on the C-C bond cleavage in an environmentally benign manner.
Synthesis and structure-activity relationship study of arylsulfonamides as novel potent H5N1 inhibitors
Yu, Yongshi,Tang, Qi,Xu, Zhichao,Li, Siliang,Jin, Mengyu,Zhao, Zixuan,Dong, Chune,Wu, Shuwen,Zhou, Hai-Bing
, p. 206 - 216 (2018/10/15)
H5N1 virus, one subtype of highly pathogenic influenza A virus in human infection, has recently received attention due to its unpredictable and high mortality. In this study, a series of arylsulfonamide derivatives were identified as improved H5N1 inhibitors for the influenza treatment by systematic structure-activity relationship investigation. Among them, the most potent H5N1 inhibitor 3h exhibited excellent antiviral activity against H5N1 virus with EC50 value of 0.006 μM and selectivity index 33543.3. Moreover, the molecular docking of 3h with M2 proton channel protein provides practical way for understanding the inhibition of H5N1 with this kind of compounds.
Thermal Electrocyclic Reactions of 2-Aza-1,3-butadiene Derivatives. A New N-Heterocyclic Annelation
Govindan, C. K.,Taylor, Grant
, p. 5348 - 5354 (2007/10/02)
A general, three-step annelation sequence, which ultimately gives 3,4-dihydro-2-quinolines and related derivatives (3), is described.The cyclization step is accomplished by pyrolysis of a 1-arenyl-2-aza-1,3-butadiene analogue (2) that apparently undergoes successive six-?-electron electrocyclization and 1,5-hydrogen migration reactions to yield the product.The conjugated azadienes, 2, are prepared by the base-catalyzed isomerization of the unconjugated isomers, 1.Compounds 1 are prepared by condensing arenyl ketones or aldehydes with 2-propenyl-1-amine.Steric effects of substituents on the azadiene chain and steric and electronic effects of the arenyl group on the cyclization step were studied.The following general conclusions were drawn: alkyl substituents R on the C=N terminus of 2 hinder a competing degradative process (commencing with a four-?-electron electrocyclization) and improve the yield of products 3; electron-withdrawing substituents on Ar of 2 or electron-withdrawing Ar groups enhance the yield of cyclized products, but they impart little regioselectivity to the reaction; regioselectivity may be imparted by ? bond fixation in Ar; electrocyclization also proceeds well with ?-electron excessive Ar groups on 2.The preferred conformation of the heterocyclic product 3 can be readily deduced by 1H NMR spectroscopy.
