751461-76-4Relevant academic research and scientific papers
SN2 displacement at the quaternary carbon center: A novel entry to the synthesis of α,α-disubstituted α-amino acids This Letter is dedicated to the late Professor Harry Wasserman, a great chemist as well as a splendid artist
Ishihara, Kotaro,Hamamoto, Hiromi,Matsugi, Masato,Shioiri, Takayuki
supporting information, p. 3169 - 3171 (2015/05/27)
A novel method for the SN2 reaction on quaternary carbon atoms using bis(p-nitrophenyl)phosphorazidate has been developed. Chiral tertiary alcohols were directly converted into the corresponding chiral tertiary azides with complete inversion of configuration. Several α,α-disubstituted α-amino esters or amino acids were prepared through the conversion of azides to the corresponding amines by catalytic hydrogenation.
Aspartame dipeptide analogues: Effect of number of side-chain methylene group spacers and C(α)-methylation in the second position
Mossel, Eric,Formaggio, Fernando,Crisma, Marco,Toniolo, Claudio,Broxterman, Quirinus B.,Boesten, Wilhelmus H.J.,Kamphuis, Johan,Quaedflieg, Peter J.L.M.,Temussi, Piero
, p. 1305 - 1314 (2007/10/03)
Our model of the active site of the sweet taste receptor is shown to be consistent with the aspartame analogues in which the L-Phe2 residue is replaced by L-(αMe)Phg, L-(αMe)Phe or L-(αMe)Hph. The analogues containing either the first or the th
