751462-82-5

Usage

Chemical structure

Piperidine derivative with a benzyl and pyridinyl substituent

Potential applications

Pharmaceutical research

Biological activities

Unknown, but has potential for further study

Safety precautions

Handle and store with care, following appropriate guidelines

Upstream product

• 10429-82-0 N-benzyl-2-chloro-N-(2-chloroethyl)ethanamine hydrochloride 
• 13121-99-8 pyridin-4-ylacetonitrile 
• 55-51-6 N,N-bis(2-chloro-ethyl)-benzenemethanamine 
• 92333-25-0 pyridin-4-ylacetonitrile hydrochloride 

Relevant academic research and scientific papers

Substituted Sulfonamide Compounds

Substituted sulfonamide compounds corresponding to the formula I: processes for the preparation thereof, pharmaceutical composition containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions.

Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonists

We recently described the synthesis and characterization of MDL 105,212, a non peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors. Here we report the synthesis and structure-activity relationships for a series of analogs of MDL 105,212 with regards to: NK1 and NK2 receptor binding affinity, physical-chemical characterization; in vitro absorption potential; in vitro metabolic stability; and efficacy in a capsaicin-challenge conscious guinea pig model after oral administration.