751479-61-5Relevant academic research and scientific papers
Polysubstituted nitrogen-containing heteroaromatic compound, and preparation method and application thereof
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Paragraph 0228-0235; 0313-0319, (2019/10/01)
The present invention relates to a preparation method of a polysubstituted nitrogen-containing heteroaromatic compound. The polysubstituted nitrogen-containing heteroaromatic compound has a structurerepresented by general formula (I) or (II). The method c
Rh-Catalyzed Reaction of Vinyl Azides with Isonitriles and Alkynes/Benzynes
Li, Zongyang,Huo, Tongyu,Li, Li,Feng, Shuo,Wang, Qian,Zhang, Zhen,Pang, Sen,Zhang, Zhiyuan,Wang, Peng,Zhang, Zhenhua
, p. 7762 - 7766 (2019/01/04)
In contrast to well-known transformations of vinyl azides via azirine intermediates or initiating at the alkene moiety, herein we report a Rh(I)-catalyzed coupling reaction of vinyl azides with isonitriles at the azide moiety to form active vinyl carbodiimide intermediates and following tandem cyclization with unsaturated compounds, such as alkynes and benzynes, to give different classes of azaheterocycles. Mechanistically, controlled experiments and DFT calculations disclose that Rh-nitrene is the vital species in the first coupling step, and the Rh(I) catalyst can also play an important role in the cyclization step of alkynes.
Synthesis of new 3-arylisoquinolinamines: Effect on topoisomerase I inhibition and cytotoxicity
Cho, Won-Jea,Min, Sun Young,Le, Thanh Nguyen,Kim, Tae Sung
, p. 4451 - 4454 (2007/10/03)
To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed.
Molecular modeling of 3-arylisoquinoline antitumor agents active against A-549. A comparative molecular field analysis study
Cho, Won-Jea,Kim, Eui-Ki,Park, Il Yeong,Jeong, Eun Young,Kim, Tae Sung,Le, Thanh Nguyen,Kim, Dae-Duk,Lee, Eung-Seok
, p. 2953 - 2961 (2007/10/03)
A series of 58 3-arylisoquinoline antitumor agents were investigated for defining the pharmacophore model using comparative molecular field analysis (CoMFA) program. The studied compounds related to bioisostere of benzophenanthridine alkaloid were synthes
