7515-50-6

Basic information

• Product Name: 3-Buten-1-ol, 4-(4-fluorophenyl)-, (E)-
• CAS NO: 7515-50-6
• Molecular Formula: C10H11FO
• Molecular Weight: 166.195
• Mol File: 7515-50-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-Buten-1-ol, 4-(4-fluorophenyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-1-ol, 4-(4-fluorophenyl)-, (E)-(7515-50-6)
• EPA Substance Registry System: 3-Buten-1-ol, 4-(4-fluorophenyl)-, (E)-(7515-50-6)

Safety Data

• Hazardous Substances Data: 7515-50-6(Hazardous Substances Data)

Upstream product

• 627-27-0 homoalylic alcohol 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 51860-45-8 3-hydroxypropyltriphenylphosphonium bromide 
• 14580-93-9 2,2,2-Triphenyl-1,2-λ⁵-oxaphospholan 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 127404-66-4 (E)-4-(4-fluorophenyl)-3-butenoic acid 
• 1250907-71-1 methyl (E)-4-(4-fluorophenyl)-3-butenoate 
• 772-31-6 cyclopropyl(4-fluorophenyl)methanone 
• 7515-48-2 (E)-1-(4-bromobut-1-en-1-yl)-4-fluorobenzene 
• 827-88-3 cyclopropyl(4-fluorophenyl)methanol 
• 7515-49-3 trans-1-(4-Fluor-phenyl)--acetat 

Downstream Products

• 1026269-76-0 (E)-4-(4-fluorophenyl)but-3-en-1-yl methanesulfonate 
• 1426692-60-5 3-chloro-2-(4-fluorophenyl)tetrahydrofuran 
• 130182-88-6 N-(4-(4-fluorophenyl)-3-butenyloxy)-phthalimide 
• 7515-58-4 1-<4-Fluor-phenyl>--β-naphthylsulfonat 

Relevant articles and documents

Palladium-Catalyzed Tandem Hydrocarbonylative Lactamization and Cycloaddition Reaction for the Construction of Bridged Polycyclic Lactams

The intramolecular hydroaminocarbonylation of alkenes is a compelling tool to rapidly access lactam, a privileged motif ubiquitous in natural products, pharmaceuticals, and agrochemicals. However, selective carbonylation to bridged polycyclic lactams with a lactam nitrogen at a bridgehead position is less explored. We herein report a modular palladium-catalyzed approach to perform a tandem hydrocarbonylative lactamization/Diels-Alder cycloaddition reaction with 2-vinyl aryl aldimines, alkenes, and CO, which offers convenient access to furnish the bridged polycyclic lactams in high yields with high selectivities.

An Enzymatic Platform for the Highly Enantioselective and Stereodivergent Construction of Cyclopropyl-δ-lactones

Abiological enzymes offers new opportunities for sustainable chemistry. Herein, we report the development of biological catalysts derived from sperm whale myoglobin that exploit a carbene transfer mechanism for the asymmetric synthesis of cyclopropane-fused-δ-lactones, which are key structural motifs found in many biologically active natural products. While hemin, wild-type myoglobin, and other hemoproteins are unable to catalyze this reaction, the myoglobin scaffold could be remodeled by protein engineering to permit the intramolecular cyclopropanation of a broad spectrum of homoallylic diazoacetate substrates in high yields and with up to 99 % enantiomeric excess. Via an alternate evolutionary trajectory, a stereodivergent biocatalyst was also obtained for affording mirror-image forms of the desired bicyclic products. In combination with whole-cell transformations, the myoglobin-based biocatalyst was used for the asymmetric construction of a cyclopropyl-δ-lactone scaffold at a gram scale, which could be further elaborated to furnish a variety of enantiopure trisubstituted cyclopropanes.

Nickel Catalyzed Regio-, Diastereo-, and Enantioselective Cross-Coupling of 3,4-Epoxyalcohol with Aryl Iodides

The first catalytic, regioselective cross-coupling of 3,4-epoxyalcohol with aryl iodides is reported. The combination of NiCl2·DME and a newly developed C2-symmetric oxazoline ligand plays a key role in selective ring opening of seve