75163-15-4

Upstream product

• 2213-63-0 2,3-dichloroquinoxaline 
• 536-74-3 phenylacetylene 
• 15804-19-0 quinoxaline-2,3-dione 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 75163-14-3 2,3-dipiperidinoquinoxaline 
• 6307-64-8 2,3-dimorpholinoquinoxaline 
• 62356-28-9 1,2-diphenyl-1H-pyrrolo[2,3-b]quinoxaline 
• 64802-09-1 2-Phenyl<1H>pyrrolo<2,3-b>quinoxaline 
• 41834-41-7 3-(phenylethynyl)quinoxalin-2-ol 
• 61290-02-6 3-Benzoyl-2-phenyl-furo<2,3-b>chinoxalin 
• 1446432-78-5 (Z)-4-(3-(2-(4-hydroxy-2-methylphenyl)-2-phenylvinyl)quinoxalin-2-yl)-3-methylphenol 

Relevant academic research and scientific papers

NaSH in the construction of thiophene ring fused with N-heterocycles: A rapid and inexpensive synthesis of novel small molecules as potential inducers of apoptosis

A facile construction of a thiophene ring fused with N-heterocycles has been achieved via the reaction of NaSH with 2-chloro-3-alkynyl quinoxalines/pyrazines leading to novel 2-substituted thieno[2,3-b]pyrazine/quinoxaline derivatives as potential inducer

Synthesis, crystal structures and properties of carbazolebased [6]helicenes fused with an azine ring

Novel carbazole-based [6]helicenes fused with an azine ring (pyridine, pyrazine or quinoxaline) have been prepared through a fivestep synthetic sequence in good overall yields. Commercially available 2, 3-dihaloazines were used as starting materials. To d

Ultrasound assisted synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives: Their in silico assessment as potential ligands for N-protein of SARS-CoV-2

In view of recent global pandemic the 3-alkynyl substituted 2-chloroquinoxaline framework has been explored as a potential template for the design of molecules targeting COVID-19. Initial in silico studies of representative compounds to assess their bindi

Synthesis and photophysical properties of selenopheno[2,3-b]quinoxaline and selenopheno[2,3-b]pyrazine heteroacenes

In this paper, we report the novel synthesis of three different heterocycles, namely 2-arylselenopheno[2,3-b]quinoxaline, 3-(aryl/alkylselanyl)-2-arylselenopheno[2,3-b]quinoxaline and 6-phenyl-7-(arylselanyl)selenopheno[2,3-b]pyrazine derivatives, from th

Synthesis and Characterization of Azine-[5]Helicene Hybrids

Novel azine-helicene hybrids (pyridine-, pyrazine- and quinoxaline-fused along the central ring [5]helicenes) have been prepared in good overall yields through a five-step synthetic sequence. Commercially available 2,3-dihaloazines were used as starting materials. To discern the effect of merging an azine moiety within a helical skeleton, the X-ray structures, UV/Vis absorption spectra, cathodic and anodic electrochemistry of the helicene hybrids were investigated and compared to that of the parent [5]helicene.

Synthesis and Characterization of Pyridine-, Pyrazine-, and Quinoxaline-Derived [4]Helicenes and S-Shaped Double [4]Helicenes

A systematic study of the synthesis and properties of 1-aza-, 4-aza-, and 1,4-diaza[4]helicenes as well as the previously unknown S-shaped double 1,4-diaza[4]helicenes has been reported. The synthetic route to the aza- and diaza[4]helicenes involved an el

Trifluoroacetic Acid Mediated One-Pot Synthesis of Furo-Fused Quinoxalines/Pyrazines

A trifluoroacetic acid promoted step-economical one-pot approach to the synthesis of furo-fused quinoxalines/pyrazines by the reaction of 2,3-dichloroquinoxalines/pyrazines with alkynes is described. The reaction involves a selective in-situ Sonogashira c

Regioselective 6-endo-dig iodocyclization: An accessible approach for iodo-benzo [a] phenazines

A facile approach for the synthesis of substituted iodo-benzo[a]phenazines from 2-aryl-3-(aryl/alkylethynyl)quinoxalines via 6-endo-dig ring closure has been described under mild reaction conditions. Iodocyclization proceeds through the iodonium ion intermediate followed by nucleophilic cyclization with the C-H bond of the arene. Furthermore, the resulting 6-iodo-5-aryl/alkyl benzo[a]phenazine derivatives allowed for structural diversification by employing various coupling reactions. The structure of iodo-benzo[a]phenazine was confirmed by X-ray crystallographic studies of the compound.

Palladium-Catalyzed Intramolecular Fujiwara-Hydroarylation: Synthesis of Benzo[a]phenazines Derivatives

An atom-economical Pd-catalyzed approach for the synthesis of benzophenazine derivatives using substituted 2-aryl-3-(aryl/alkylethynyl) quinoxaline in the presence of trifluoroacetic acid at 65 °C has been described. The chemistry involves in situ generation of cationic Pd(II) species, which functionalized the aromatic C-H bonds via electrophilic metalation followed by concomitant intramolecular trans-insertion of C-C triple bond to aryl-Pd complex. The results were supported by various control experiments including with electron-deficient arenes and deuterium labeling studies. The deuterium labeling studies supports electrophilic palladation of aromatic C-H over activation of C-C triple bond of alkyne. The structure of synthesized compounds was further confirmed by X-ray crystallography studies. This catalytic protocol has been efficiently applied for novel synthesis of highly functionalized benzo fused phenazines.

Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: An unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis

The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy h