64802-09-1Relevant academic research and scientific papers
Pyrrolo[2,3-b]quinoxalines as inhibitors of firefly luciferase: Their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay
Nakhi, Ali,Rahman, Md. Shafiqur,Kishore, Ravada,Meda, Chandana Lakshmi T.,Deora, Girdhar Singh,Parsa, Kishore V.L.,Pal, Manojit
, p. 6433 - 6441 (2012/11/07)
2-Substituted pyrrolo[2,3-b]quinoxalines having free NH were prepared directly from 3-alkynyl-2-chloroquinoxalines in a single pot by using readily available and inexpensive methane sulfonamide (or p-toluene sulfonamide) as an ammonia surrogate. The reaction proceeded in the presence of Cu(OAc)2 affording the desired product in moderate yield. The crystal structure analysis of a representative compound and its supramolecular interactions are presented. Some of the compounds synthesized exhibited inhibitory activities against luciferase that was supported by the predictive binding mode of these compounds with luciferase enzyme through molecular docking studies. The key observations disclosed here can alert users of luciferase reporter gene assays for possible false positive results due to the direct inhibition of luciferase.
2,3-Disubstituted pyrrolo[2,3-b]quinoxalines via aminopalladation- reductive elimination
Arcadi, Antonio,Cacchi, Sandro,Fabrizi, Giancarlo,Parisi, Luca M.
, p. 2431 - 2434 (2007/10/03)
2,3-Disubstituted pyrrolo[2,3-b]quinoxalines have been prepared in good to high yield through the reaction of 2-alkynyl-3-trifluoroacetamidoquinoxalines with aryl and vinyl halides or triflates in the presence of Pd(PPh 3)4 and K2CO3 in MeCN at 100°C.
2-Aryl and 2-Heteroaryl Pyrrolo[2,3-b]quinoxalines via Copper-Catalyzed Reaction of 1-Alkynes with 2-Bromo-3-trifluoroacetamidoquinoxaline
Cacchi, Sandro,Fabrizi, Giancarlo,Parisi, Luca M.,Bernini, Roberta
, p. 287 - 290 (2007/10/03)
2-Aryl and 2-heteroaryl pyrrolo[2,3-b]quinoxalines have been prepared in good to high yield through the reaction of 1-alkynes with 2-bromo-3- trifluoroacetamidoquinoxaline in the presence of catalytic amounts of CuI, PPh3, and K2CO3 in dioxane at 110°C. The reaction appears to tolerate a wide range of functionalized 1-alkynes, including those containing ether, alcohol, amide, aldehyde, ketone, ester, and nitro groups.
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects
Mettey, Yvette,Gompel, Marie,Thomas, Virginie,Garnier, Matthieu,Leost, Maryse,Ceballos-Picot, Irène,Noble, Martin,Endicott, Jane,Vierfond, Jean-Michel,Meijer, Laurent
, p. 222 - 236 (2007/10/03)
Cyclin-dependent kinases (CDKs) regulate the cell cycle, apoptosis, neuronal functions, transcription, and exocytosis. The observation of CDK deregulations in various pathological situations suggests that CDK inhibitors may have a therapeutic value. In th
Reactions of β-(lithiomethyl)azines with nitriles as a route to pyrrolo-pyridines, - quinolines, -pyrazines, - quinoxalines and -pyrimidines
Davis, Michael L.,Wakefield, Basil J.,Wardell, Jacklyn A.
, p. 939 - 952 (2007/10/02)
Deprotonation of 3-methylazines, followed by reaction with benzonitile, gives an intermediate which, on treatment with additional strong base, cyclises to give 2-phenyl[1H]-pyrrolo[2,3-b]pyridine. The application of this type of reaction to a variety of n
