7517-39-7

Upstream product

• 85-44-9 phthalic anhydride 
• 107-21-1 ethylene glycol 
• 106-93-4 ethylene dibromide 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Downstream Products

• 1221686-79-8 ethylenediammonium 2,2'-[ethane-1,2-diylbis(oxycarbonyl)]dibenzoate 

Relevant academic research and scientific papers

Synthesis and crystal structure of some macrocyclic ring compounds

A bola-shaped diester-dicarboxylic acid (L1H2) synthesized with ethanediol spacer and phthalic anhydride head group is demonstrated to form various macrocyclic ring compounds such as M1, M2, and M3. Compound M1, containing both lactam [-C(=O)-N-H)] and lactone [-C(=O)-O-] functional groups, has a [16]-membered macrocyclic ring, while compound M2, composed of only lactones [-C(=O)-O-], exists with a [19]-membered macrocyclic ring. Similarly, compound M3, composed of Cu(II) metal ions, exists with a macrocycle-like [15]-membered chelate ring. In addition to the 1H NMR spectra, the single crystals obtained for M1 and M3 thoroughly established, the formation of the ring structures. This article demonstrates the versatile capability of diester-dicarboxylic acid for forming various types of ring compounds, such as bis-chelate rings in M3 and lactam cum lactone-type macrocyclic rings in M1 and M2.

Synthesis, characterization and superoxide dismutase activity of bi-copper(II)-bisacetato- μ-phthalicacid[bis(benzyloxy)ethyl]ester

A new binuclear copper(II) complex, bridged by the ligand phthalicacid[bis(benzyloxy)ethyl]ester, where each copper(II) is coordinated to one carboxylate (from ligand) and one acetate in square planar mode is reported. The ligand synthesized by the reaction of phthalic anhydride and ethylene glycol, has been characterized by FT-IR, 1HNMR and LCMS. The binuclear Copper(II) complex has been characterized by UV/visible spectra, FTIR spectra, EPR spectra, ESI-MS spectra, magnetic moment measurement and thermogravimetric analysis. DFT calculation has shown a Z type structure for the complex. Excellent superoxide dismutase activity with IC50 value 8.6 ×10-6 M for the complex has been observed. [Figure not available: see fulltext.]

Synthesis of macrocyclic compounds with steric barriers in macroheterocycle proceeding from (Z)-1,2,3,6-tetrahydrophthalic and phthalic acids

Using 1,2-dibromoethane, (E)-1,4-dibromo-2-butene, (Z)-1,2,3,6-tetrahydrophthalic and phthalic acids we obtained along [1+1] scheme uncommon macrocyclic compounds containing ester groups, multiple bonds, and amide moieties in the macroheterocycle. The neu

Hydrogen bonded helices: Synthesis, crystal structure and self-assembled microtubes

Dicarboxylic bola-shaped compounds 1-3, possessing phthalyl head groups and diol spacers are synthesized and characterized. Keeping phthalyl head group common for all three diester-dicarboxylic acids, the spacer moiety is systematically altered by two and four carbon atoms in 1 and 2, 3, respectively. The flexible spacer moiety ethane-1,2-diol in compound 1 is replaced by cis-but-2-ene-1,4-diol and 1,4-butane diol in 2 and 3, respectively, to study the effect on the morphology of the microcrystal grown on them. Thus compound 2 and 3 though posses four carbon atoms in their respective spacer moiety, they differ by their rigidity. The single crystal X-ray structure obtained for 1, 2 and 3 indicates the formation of self-assembled single stranded helical structure mediated through O-H...O interaction of the end carboxylic acids. Interestingly compound 1 self-assembled into microtubes in ethanol:water solvent mixture. The solvent and the O-H...O; C-H...O interaction combinedly play crucial role in molecular self-assembly process and defines the morphology for 1 into "microtube" whereas 2 and 3 forming "bar" fails to produce such tubular texture though their respective crystal structure shows single stranded helices. The role of weak C-H...O interaction, incorporation of rigid spacer and various other factors such as polarity of the solvents are discussed in detail to explore the difference in the morphology.