75184-94-0

Usage

Uses

Bronchodilator (anti-allergic).

InChI:InChI=1/C16H16ClN5O/c1-16(2)8-22-14(23)12-13(19-9-18-12)21(15(22)20-16)7-10-3-5-11(17)6-4-10/h3-6,9H,7-8H2,1-2H3,(H,18,19)

Upstream product

• 79013-31-3 5,5-Dimethyl-2-methylsulfanyl-4,5-dihydro-1H-imidazole; hydriodide 
• 75184-73-5 7-Amino-8-(4-chloro-benzyl)-2,2-dimethyl-6-nitroso-2,8-dihydro-3H-imidazo[1,2-a]pyrimidin-5-one 
• 104-86-9 4-chlorobenzylamine 
• 75184-74-6 N-[7-Amino-8-(4-chloro-benzyl)-2,2-dimethyl-5-oxo-2,3,5,8-tetrahydro-imidazo[1,2-a]pyrimidin-6-yl]-formamide 

Downstream Products

• 75185-19-2 1-(2-amino-2,2-dimethylethyl)-3-<(4-chlorophenyl)methyl>-7(9H)-purine-2,6(1H,3H)-dione 

Relevant academic research and scientific papers

Substituted 6,7-dihydroimidazo[1,2-al]purin-9 (4H)-ones

The synthesis of a series of substituted 6,7-dihydroimidazo[1,2-a]purin-9(4H)-ones is described. Several members of the series exhibit enhanced antiallergic and bronchodilator activity and reduced side effects as compared to theophylline. Structure-activity relationships and metabolic considerations are discussed for the series. Analogues substituted with a 4-(4-chlorobenzyl) moiety, such as 33 and 40, show an optimal balance of antiallergic and bronchodilator activity and are of particular interest. Compound 33 is significantly more potent than theophylline against both metacholine- and antigen-induced bronchospasms, does not affect spontaneous motor activity, and shows minimal cardiovascular effects in the rat.