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Ethyl 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidine-4-carboxylate 2-oxide is a complex organic compound with the chemical formula C7H13Cl4N2O3P. It is a derivative of the oxazaphospholidine family, which are heterocyclic compounds containing phosphorus, oxygen, and nitrogen atoms. This specific compound features a phosphorus atom bonded to an ethyl group, a carboxylate group, and a bis(2-chloroethyl)amino group. The presence of two chlorine atoms on each of the ethyl groups attached to the nitrogen atom gives ethyl 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidine-4-carboxylate 2-oxide its unique structure. It is primarily used in the pharmaceutical industry as a precursor in the synthesis of various drugs, particularly those with anticancer properties. Due to its complex structure and potential applications, ethyl 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidine-4-carboxylate 2-oxide is of interest to researchers in medicinal chemistry and drug development.

7521-84-8

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7521-84-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7521-84-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,2 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 7521-84:
(6*7)+(5*5)+(4*2)+(3*1)+(2*8)+(1*4)=98
98 % 10 = 8
So 7521-84-8 is a valid CAS Registry Number.

7521-84-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ<sup>5</sup>-oxazaphospholidine-4-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:7521-84-8 SDS

7521-84-8Downstream Products

7521-84-8Relevant academic research and scientific papers

Synthesis and antitumor evaluation of 4-ethoxycarbonyl cyclophosphamide analogs

Foster

, p. 709 - 710 (1978)

4 Ethoxycarbonyl analogs of cyclophosphamide and its five-membered ring homolog were synthesized utilizing the cyclization method previously described. N,N Bis(2 chloroethyl) 4 ethoxycarbonyl 1,3,2 oxazaphospholidin 2 amine 2 oxide demonstrated activity against L 1210 lymphoid leukemia whereas N,N bis(2 chloroethyl) 4 (ethoxycarbonyl)tetrahydro 2H 1,3,2 oxazaphosphorin 2 amine 2 oxide did not. The oxazaphosphorin 2 amine was evaluated against human epidermoid carcinoma of the nasopharynx (cell culture). The results again were negative: ED50=2.8x10.

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