7521-84-8

Basic information

• Product Name: ethyl 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidine-4-carboxylate 2-oxide
• CAS NO: 7521-84-8
• Molecular Formula: C₉H₁₇Cl₂N₂O₄P
• Molecular Weight: 319.122
• Mol File: 7521-84-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 389.9°C at 760 mmHg
• Flash Point: 189.6°C
• Density: 1.37g/cm³
• Vapor Pressure: 2.76E-06mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: ethyl 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidine-4-carboxylate 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidine-4-carboxylate 2-oxide(7521-84-8)
• EPA Substance Registry System: ethyl 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidine-4-carboxylate 2-oxide(7521-84-8)

Safety Data

• Hazardous Substances Data: 7521-84-8(Hazardous Substances Data)

Upstream product

• 127-88-8 N,N-di(2-chloroethyl)amidophosphoric acid dichloride 
• 3940-27-0 serine ethyl ester hydrochloride 

Relevant articles and documents

Synthesis and antitumor evaluation of 4-ethoxycarbonyl cyclophosphamide analogs

4 Ethoxycarbonyl analogs of cyclophosphamide and its five-membered ring homolog were synthesized utilizing the cyclization method previously described. N,N Bis(2 chloroethyl) 4 ethoxycarbonyl 1,3,2 oxazaphospholidin 2 amine 2 oxide demonstrated activity against L 1210 lymphoid leukemia whereas N,N bis(2 chloroethyl) 4 (ethoxycarbonyl)tetrahydro 2H 1,3,2 oxazaphosphorin 2 amine 2 oxide did not. The oxazaphosphorin 2 amine was evaluated against human epidermoid carcinoma of the nasopharynx (cell culture). The results again were negative: ED50=2.8x10.