Journal of Pharmaceutical Sciences p. 709 - 710 (1978)
Update date:2022-08-03
Topics:
Foster
4 Ethoxycarbonyl analogs of cyclophosphamide and its five-membered ring homolog were synthesized utilizing the cyclization method previously described. N,N Bis(2 chloroethyl) 4 ethoxycarbonyl 1,3,2 oxazaphospholidin 2 amine 2 oxide demonstrated activity against L 1210 lymphoid leukemia whereas N,N bis(2 chloroethyl) 4 (ethoxycarbonyl)tetrahydro 2H 1,3,2 oxazaphosphorin 2 amine 2 oxide did not. The oxazaphosphorin 2 amine was evaluated against human epidermoid carcinoma of the nasopharynx (cell culture). The results again were negative: ED50=2.8x10.
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Doi:10.1039/P19800001477
(1980)Doi:10.1007/BF00958823
(1980)Doi:10.1002/ardp.19803130808
(1980)Doi:10.1016/0040-4039(80)80028-1
(1980)Doi:10.1021/ic50215a049
(1981)Doi:10.1016/S0040-4039(00)01309-5
(2000)
