75211-12-0Relevant academic research and scientific papers
Arylformamidines with Antinociceptive Properties
Gall, M.,McCall, J. M.,TenBrink, R. E.,VonVoigtlander, P. F.,Mohrland, J. S.
, p. 1816 - 1820 (1988)
A series of formamidines structurally related to clondine were synthesized and investigated as potential nonopiate analgesics.Several of these compounds showed potent analgesic activity (ED50 on HCl writhing 1.0 mg/kg) with low potential for hypotensive effects.A qualitative description of the structure-activity relationship of this series reveals that the 2,4- and 2,6-dimethylphenyl compounds are more potent analgesics than are the corresponding dichlorophenyl compounds.
