Journal of Medicinal Chemistry p. 1816 - 1820 (1988)
Update date:2022-08-02
Topics:
Gall, M.
McCall, J. M.
TenBrink, R. E.
VonVoigtlander, P. F.
Mohrland, J. S.
A series of formamidines structurally related to clondine were synthesized and investigated as potential nonopiate analgesics.Several of these compounds showed potent analgesic activity (ED50 on HCl writhing <1.0 mg/kg) with low potential for hypotensive effects.A qualitative description of the structure-activity relationship of this series reveals that the 2,4- and 2,6-dimethylphenyl compounds are more potent analgesics than are the corresponding dichlorophenyl compounds.
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