75218-53-0

Basic information

• Product Name: 2-[4-(benzyloxy)-2-(hydroxymethyl)-5-methoxyphenyl]-N-[2-(thiophen-3-yl)ethyl]acetamide
• CAS NO: 75218-53-0
• Molecular Formula: C₂₃H₂₅NO₄S
• Molecular Weight: 411.5139
• Mol File: 75218-53-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 659.8°C at 760 mmHg
• Flash Point: 352.8°C
• Density: 1.232g/cm³
• Vapor Pressure: 2.63E-18mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 2-[4-(benzyloxy)-2-(hydroxymethyl)-5-methoxyphenyl]-N-[2-(thiophen-3-yl)ethyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(benzyloxy)-2-(hydroxymethyl)-5-methoxyphenyl]-N-[2-(thiophen-3-yl)ethyl]acetamide(75218-53-0)
• EPA Substance Registry System: 2-[4-(benzyloxy)-2-(hydroxymethyl)-5-methoxyphenyl]-N-[2-(thiophen-3-yl)ethyl]acetamide(75218-53-0)

Safety Data

• Hazardous Substances Data: 75218-53-0(Hazardous Substances Data)

Usage

### Properties

1. Chemical Structure:
Contains a benzene ring connected to a methoxyphenyl group.
Methoxyphenyl group is further connected to an acetamide group.
Includes a thiophenyl group as a substituent.
2. Functional Groups:
Benzyl ether (benzyloxy)
Hydroxymethyl
Methoxy
Acetamide
Thiophenyl
3. Potential Pharmaceutical Applications:
Structural features suggest potential pharmaceutical applications.
Functional groups may influence solubility, bioavailability, and biological target affinity.
4. Need for Further Research:
Requires additional research to explore its potential uses and effects.

Benzene Ring

Core aromatic structure.

Methoxyphenyl Group (Substituted Phenyl Ring)

Attached to the benzene ring.
Contains methoxy (methoxyoxy) and hydroxymethyl (benzyloxy) groups.

Acetamide Group

Attached to the methoxyphenyl group.
Consists of an amide (-CONH2) functional group.

Thiophenyl Group

Substituent attached to the acetamide group.
Consists of a thiophene ring.

This compound's complex structure and diverse functional groups suggest potential pharmacological significance, emphasizing the need for further investigation to uncover its specific applications and effects.

Upstream product

• 59311-67-0 2-(3-thienyl)ethylamine 
• 62726-53-8 7-(benzyloxy)-6-methoxyisochroman-3-one 

Downstream Products

• 75218-51-8 8-Benzyloxy-9-methoxy-4,6,11,11a-tetrahydro-5H-1-thia-5a-aza-cyclopenta[a]anthracene; hydrochloride 
• 688301-90-8 9-benzyloxy-10-methoxy-7H-4,5,12,12a-tetahydrobenzothieno<2,3-a>quinolizine 

Relevant articles and documents

STUDIES ON HETEROCYCLIC COMPOUNDS VI. Synthesis of Thiophene Isoesters of Protoberberine Alkaloids

Synthesis of thiophene isosters of protoberberine alkaloids (6, 12, 19) is described.The Mannich type reaction of the tetrahydroisoquinolines (5, 11) and the thienopyridine (18) with formaldehyde in glacial acetic acid afforded the title compounds.Cyclization of the tetrahydroisoquinoline derivative (23) failed to furnish the D-ring protoberberine isoster (25), but gave an unexpected product, the oxazepinoisoquinoline derivative (24).The conversion of the compound (24) to the 2-substituted isoquinoline (27) is also described.