752228-17-4Relevant academic research and scientific papers
Stereocontrolled one-pot synthesis of cycloalkane derivatives possessing a quaternary carbon using allyl phenyl sulfone
Ota, Koichiro,Kurokawa, Takao,Kawashima, Etsuko,Miyaoka, Hiroaki
, p. 8668 - 8676 (2009)
Stereocontrolled one-pot synthesis of cyclopentane derivatives possessing quaternary carbon using allyl phenyl sulfone and epoxyiodide was presented. Furthermore, application of this protocol to the synthesis of cycloalkane derivatives with different ring
New metal-free one-pot synthesis of substituted allenes from enones
Tang, Meng,Fan, Chun-An,Zhang, Fu-Min,Tu, Yong-Qiang,Zhang, Wen-Xue,Wang, Ai-Xia
supporting information; experimental part, p. 5585 - 5588 (2009/06/18)
(Chemical Equation Presented) A new metal-free, one-pot synthesis of substituted allenes from enones was discovered for the first time, in which a tertiary amine as a base was found to be an effective promoter in such novel transformations. The present synthetic protocol proceeded readily with high compatibility of sensitive functional groups, and it provides a new efficient way to access a series of synthetically important allenes without the use of metallic reagents or catalysts.
Bifunctional molecular linchpins: A three-component coupling protocol employing 2-bromoallyltrimethylsilane
Smith III, Amos B.,Duffey, Matthew O.
, p. 1363 - 1366 (2007/10/03)
A new three-component coupling protocol, exploiting 2- bromoallyltrimethylsilane as a bifunctional linchpin, has been developed. The reaction sequence entails the following steps: lithiation of the vinyl bromide, addition of an aromatic or aliphatic aldehyde, execution of a solvent controlled 1,4-Brook rearrangement induced by HMPA to generate an allyl anion, and addition of a reactive second electrophile. Yields are moderate to good.
