922-63-4Relevant articles and documents
Solvent effect on the rate of the Mannich reaction of butyraldehyde with formaldehyde
Marshalok,Karpyak,Makitra,Polyuzhin
, p. 1264 - 1268 (2006)
The Mannich reaction of formaldehyde with butyraldehyde and diethylamine in hydrophilic solvents ensuring homogeneity of the medium follows the kinetic relations typical of an irreversible second-order reaction. The rate constants are determined by the ability of solvents to undergo self-association and their electrophilic solvation power; additional inclusion of the solvent polarity via multiparameter Koppel'-Pal'm equation is necessary to obtain a satisfactory quantitative correlation.
PREPARING METHOD OF DIMETHYLOLBUTANAL AND PREPERATION METHOD OF TRIMETHYLOLPROPANE USING THE SAME
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Paragraph 0025; 0056-0059; 0073-0079; 0082-0085; 0090, (2021/02/16)
A method for preparing dimethylolbutanal according to one embodiment of the present application comprises the steps of: performing a first aldol reaction with n-butylaldehyde and a first formaldehyde under a first alkylamine catalyst to prepare a first active ingredient including dimethylol butanal and a by-product including ethyl acrolein; performing a distillation process to separate the by-product including the ethyl acrolein; and performing a second aldol reaction with the separated by-product including ethyl acrolein and a second formaldehyde under a second alkylamine catalyst to prepare a second active ingredient including dimethylol butanal.
Three Ways Aliphatic Aldehydes React with Nonstabilized Azomethine Ylides
Buev, Evgeny M.,Gorbunova, Evgeniya V.,Moshkin, Vladimir S.,Sosnovskikh, Vyacheslav Y.
supporting information, p. 343 - 348 (2020/02/27)
Aliphatic aldehydes readily react with nonstabilized azomethine ylides in one of the three ways to give oxazolidines, pyrrolidines, or Mannich bases, depending on the structure of the starting compound and the reaction conditions. The use of N -(methoxymethyl)- N -[(trimethylsilyl)methyl]benzylamine in DMF provided 5-alkyloxazolidines in 40-97percent yields. On the other hand, three-component reactions of aliphatic aldehydes bearing one α-hydrogen with N -methyl(benzyl)glycine and formaldehyde gives Mannich bases in yields of 47-98percent. A similar reaction of aldehydes bearing branched alkyl groups and two hydrogen atoms at the α-position proceeds as a domino process that gives 3-alkyl-3-formylpyrrolidines in yields of 34-93percent.
