752241-82-0Relevant articles and documents
Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators
Iino, Tomoharu,Tsukahara, Daisuke,Kamata, Kenji,Sasaki, Kaori,Ohyama, Sumika,Hosaka, Hideka,Hasegawa, Takuro,Chiba, Masato,Nagata, Yasufumi,Eiki, Jun-ichi,Nishimura, Teruyuki
experimental part, p. 2733 - 2743 (2009/09/08)
Identification and synthesis of novel 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as glucokinase activators are described. Removal of an aniline structure of the prototype lead (2a) and incorporation of an alkoxy or phenoxy substituent led to the identifica
HETEROARYLCARBAMOYLBENZENE DERIVATIVE
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Page/Page column 45, (2008/06/13)
Compounds having glucokinase activating effects and being useful as treatments for diabetes, which are represented by the following formula (I): [wherein X1 represents oxygen, etc., X2 represents oxygen, etc., R1 represents a group on Ring A such as alkylsulfonyl, etc., R2 represents C3-7 cyclic alkyl optionally substituted with a halogen, etc., R3 represents a substituent on Ring B such as lower alkyl, etc., formula (II): represents 6- to 10-membered aryl, etc., and formula (III): represents monocyclic or bicyclic heteroaryl optionally having on Ring B a substituent represented by R3 above, wherein the carbon atom of Ring B which is bonded to the nitrogen atom of the amide group of formula (I) forms a C=N bond with the nitrogen atom of the ring], as well as their pharmaceutically acceptable salts.
