752244-60-3Relevant academic research and scientific papers
A highly stereospecific and efficient synthesis of homopentafluorophenylalanine
Babu, I. Ramesh,Hamill, Edward K.,Kumar, Krishna
, p. 5468 - 5470 (2004)
A short and efficient synthesis of homopentafluorophenylalanine (6) from oxazolidine aldehyde 1 in 57% overall yield and in >98% ee is described. The enantiomeric excess of the product was determined by 19F NMR analysis of the coupling product derived from 5 and L-Ser(O-t-Bu)-OCH3, by comparison to a dipeptide obtained from racemic 5.
