752253-57-9Relevant academic research and scientific papers
Synthesis and Analgesic-Anti-inflammatory Activities of Some 1,2, 4-Triazine Derivatives
Makhlouf, Abdelmoneim A.,Maklad, Yousreya A.
, p. 42 - 49 (2007/10/03)
A variety of novel N-arylidene-N′-[5-(4-isobutylphenyl)-[1,2,4]- triazin-3-yl]hydrazines 4, carboxylic acid N′-(5-(4-isobutylphenyl)-[1,2, 4]-triazin-3-yl]hydrazides 5, triazolotriazines 6 and other related triazine derivatives were synthesized. Several synthetic routes were employed to access the desired compounds from 5-(4-isobutylphenyl)-[1,2,4]-triazin-3-yl hydrazine 3 as a parent compound. The analgesic and anti-inflammatory activities of the synthesized compounds were studied. The results showed that compound 4g exhibited pronounced analgesic activity, while compound 4f displayed the highest anti-inflammatory activity. Meanwhile, compound 6d evoked dual analgesic-anti-inflammatory effect without any ulcerogenicity.
