7523-27-5Relevant academic research and scientific papers
BIPOLAR TRANS CAROTENOID SALTS AND USES THEREOF
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, (2018/10/26)
PROBLEM TO BE SOLVED: To provide compounds useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans. SOLUTION: There is provided a compound which has a structure represented by YZ-TCRO-ZY and is not trans sodium crocetinate [where, Y is a cation; Z is a polar group which is associated with the cation; and TCRO is trans carotenoid skeleton], and preferably, Y is a monovalent metal ion selected from the group consisting of Na+, K+ and Li+, or is an organic cation selected from the group consisting of R4 N+ and R3S+ [R is H, or CnH2n+1(n is 1 to 10)]. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT
BIPOLAR TRANS CAROTENOID SALTS AND THEIR USE
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, (2018/10/31)
PROBLEM TO BE SOLVED: To provide trans carotenoid salt compounds useful for improving the diffusibility of oxygen between red blood cells and a body tissue in mammalian including human being, a method for producing them, a method for solubilizing them, and a method for using them. SOLUTION: There are provided compounds represented by the following formula, and are compounds not being trans sodium crocetinate: YZ-TCRO-ZY[Y denotes a cation; Z denotes a polar group coupled to the cation; TCRO denotes a trans carotenoid skeleton; preferably, as follows; Y denotes the monovalent metal ion of Na+,K+ or Li+ or R4 N+ or R3S+;R denotes H or CnH2n+1;n denotes the integer of 1 to 10;Z denotes a carboxyl group, a sulfuric acid group, a mono-phosphoric acid group, a di-phosphoric acid group, or a tri-phosphoric acid group; and TCRO denotes a group using isopronoid in which the single bond and double bond of straight chain carbon and carbon as exemplified by the following formula is repeated (X respectively independently denotes H, a straight chain/branched carbon chain substituted/non-substituted with 1 to 10C halogen or a halogen)]. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPO&INPIT
Phosphane-catalyzed [3+2] annulation of allenoates with aldehydes: A simple and efficient synthesis of 2-alkylidenetetrahydrofurans
Xu, Silong,Zhou, Lili,Ma, Renqin,Song, Haibin,He, Zhengjie
supporting information; experimental part, p. 8698 - 8702 (2010/03/25)
A phosphane-catalyzed [3 +2] annulation of γ-methyl allenoates with aromatic aldehydes has been reported. This annulation provides a convergent and efficient synthesis of 2-alkylidenetetrahydrofurans, which are versatile synthetic building blocks for a vast array of 5-membered oxygenated heterocycle derivatives. The EIZ isomers of 2-(ethoxycarbonylmethylene) tetrahydrofurans, was separated by column chromatography on silica gel and their structural assignments were confirmed by H and C NMR spectroscopy data and X-ray crystallographic analysis. The nature of the substituent, as well as the reaction conditions, has a significant influence on the reactivity patterns of γ-substituted allenoates with aldehydes. The phosphorus ylide, generated from the phosphonium dienolate 8 by an overall 1,4-hydrogen shift, is believed to be the key intermediate responsible for the [3 + 2] annulation and other transformations of γ-methyl allenoates with aldehydes.
BIPOLAR TRANS CAROTENOID SALTS AND THEIR USES
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Page/Page column 26, (2008/06/13)
The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
Bipolar trans carotenoid salts and their uses
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Page 8; 10, (2008/06/13)
The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
Synthesis and characterization of all-E (12,12'-13C2)-, (13,13'-13C2)-, (14,14'-13C2)-, (15,15'-13C2)- and (20,20'-13C2)astaxanthin
Jansen, F. J. H. M.,Kwestro, M.,Schmitt, D.,Lugtenburg, J.
, p. 552 - 562 (2007/10/02)
The all-E isomers of (12,12'-13C2)-, (13,13'-13C2)-, (14,14'-13C2)-, (15,15'-13C2)- and (20,20'-13C2)astaxanthin were prepared by total synthesis starting from commercially available 99percent 13C-enriched acetonitrile, acetic acid and methyl iodide.The astaxanthins were obtained in high purity and with high isotope incorporation (>99percent for every position).For this synthesis, the C15 + C10 + C15 strategy was used.The central C10-synthon, 2,7-dimethylocta-2,4,6-triene-1,8-dial, was symmetrically dilabelled at any position using two new synthetic schemes.The 13C2-enriched C10-dialdehydes were then converted in one step to the 13C2-enriched astaxanthins.
