75230-55-6Relevant articles and documents
Ru(ii)-Catalyzed, Cu(ii)-mediated carbene migratory insertion in the synthesis of trisubstituted pyrroles from isoxazoles
Kumar, Pravin,Keshri, Santosh Kumar,Kapur, Manmohan
supporting information, p. 3428 - 3433 (2021/05/03)
A convenient, “one-pot” synthesis of trisubstituted pyrrolesviaa Ru(ii)-catalyzed, Cu(ii)-mediated reaction of substituted isoxazoles with sulfonylhydrazones has been developed. A series of highly functionalized pyrroles are obtainedviaa synergistic forma
Copper-catalyzed one-pot coupling reactions of aldehydes (ketones), tosylhydrazide and 2-amino(benzo)thiazoles: An efficient strategy for the synthesis of N-alkylated (benzo)thiazoles
Xie, Zengyang,Chen, Ruijiao,Ma, Mingfang,Kong, Lingdong,Liu, Jun,Wang, Cunde
, (2019/08/16)
An efficient and practical C–N bond formation methodology for the synthesis of N-alkylated (benzo)thiazoles was developed, via the copper-catalyzed one-pot two-step reactions of 2-amino(benzo)thiazoles and aldehydes (ketones) with tosylhydrazide. This cross-coupling reaction proceeded smoothly and tolerated a broad range of functional groups (46 examples). A variety of functionalized N-alkylated (benzo)thiazoles were obtained in moderate to high yields. Notably, gram-scale synthesis of fanetizole (anti-inflammatory drug) was also realized through this protocol.
Copper-Catalyzed Reductive N-Alkylation of Amides with N-Tosylhydrazones Derived from Ketones
Xu, Peng,Qi, Fu-Ling,Han, Fu-She,Wang, Yan-Hua
supporting information, p. 2030 - 2034 (2016/07/28)
A CuI-catalyzed reductive coupling of ketone-derived N-tosylhydrazones with amides is presented. Under the optimized conditions, an array of N-tosylhydrazones derived from aryl–alkyl and diaryl ketones could couple effectively with a wide variety of (hete