75920-46-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-CHLORO-PHENYL)-PROPIONITRILE is used as a chemical intermediate for the production of various pharmaceuticals. Its unique structure allows it to be a key component in the synthesis of drugs that target specific medical conditions, contributing to the development of novel therapeutic agents.
Used in Dye Industry:
In the dye industry, 2-(2-CHLORO-PHENYL)-PROPIONITRILE is employed as a precursor in the manufacturing process of different types of dyes. Its chemical properties make it suitable for creating dyes with specific color characteristics and stability, enhancing the range of color options available for various applications.
Used in Organic Synthesis:
2-(2-CHLORO-PHENYL)-PROPIONITRILE is used as a building block in the synthesis of a broad spectrum of organic compounds. Its reactivity and structural features enable the creation of complex organic molecules for use in various industries, including chemical, material science, and research.
Safety Precautions:

Upstream product

• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 67-56-1 methanol 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 75230-55-6 N’-(1-(2-chlorophenyl) ethylidene)-4-methylbenzenesulfonohydrazide 
• 333-20-0 potassium thioacyanate 
• 74-88-4 methyl iodide 

Downstream Products

• 1338547-05-9 C₁₄H₁₉BrClNO₂ 
• 1338547-04-8 N-(2-(4-bromo-2-chlorophenyl)propyl)-2,2,2-trifluoroacetamide 
• 2184-85-2 2-(2-chloro-phenyl)-propanoic acid 

Relevant academic research and scientific papers

Sustainable Alkylation of Nitriles with Alcohols by Manganese Catalysis

A general and chemoselective catalytic alkylation of nitriles using a homogeneous nonprecious manganese catalyst is presented. This alkylation reaction uses naturally abundant alcohols and readily available nitriles as coupling partners. The reaction tolerates a wide range of functional groups and heterocyclic moieties, efficiently providing useful cyanoalkylated products with water as the only side product. Importantly, methanol can be used as a C1 source and the chemoselective C-methylation of nitriles is achieved. The mechanistic investigations support the multiple role of the metal-ligand manganese catalyst, the dehydrogenative activation of the alcohol, α-C-H activation of the nitrile, and hydrogenation of the in-situ-formed unsaturated intermediate.

Cyanide-Free and Broadly Applicable Enantioselective Synthetic Platform for Chiral Nitriles through a Biocatalytic Approach

A cyanide-free platform technology for the synthesis of chiral nitriles by biocatalytic enantioselective dehydration of a wide range of aldoximes is reported. The nitriles were obtained with high enantiomeric excess of >90 % ee (and up to 99 % ee) in many cases, and a “privileged substrate structure” with respect to high enantioselectivity was identified. Furthermore, a surprising phenomenon was observed for the enantiospecificity that is usually not observed in enzyme catalysis. Depending on whether the E or Z isomer of the racemic aldoxime substrate was employed, one or the other enantiomer of the corresponding nitrile was formed preferentially with the same enzyme.

Copper-Catalyzed Cyanation of N-Tosylhydrazones with Thiocyanate Salt as the "cN" Source

A novel protocol for the synthesis of α-aryl nitriles has been successfully achieved via a copper-catalyzed cyanation of N-tosylhydrazones employing thiocyanate as the source of cyanide. The features of this method include a convenient operation, readily available substrates, low-toxicity thiocyanate salts, and a broad substrate scope.

TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME

Trycyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.