75235-35-7

Usage

Uses

Used in Pharmaceutical Production:
2-(ethylamino)-2-oxoacetic acid is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs, enhancing their therapeutic properties.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-(ethylamino)-2-oxoacetic acid is utilized for the creation of a range of organic compounds, contributing to the development of new chemical entities with potential applications in various industries.
Used in Metal Ion Coordination Chemistry:
2-(ethylamino)-2-oxoacetic acid is used as a chelating agent in metal ion coordination chemistry, where it forms complexes with metal ions. This property is valuable for applications such as environmental remediation, where it can help in the sequestration and removal of toxic metal ions, and in the development of catalysts for chemical reactions.
It is crucial to handle and store 2-(ethylamino)-2-oxoacetic acid according to proper safety procedures to mitigate any potential hazardous effects.

Upstream product

• 20943-60-6 ethyl 2-(ethylamino)-2-oxoacetate 
• 1159923-15-5 N-ethyl-2,3-dioxo-3-phenylpropanamide 
• 7732-18-5 water 

Downstream Products

• 626-36-8 ethyl allophanate 
• 51-79-6 urethane 
• 75-04-7 ethylamine 

Relevant academic research and scientific papers

Oxamic acid analogues as LDH-C4-specific competitive inhibitors

We performed kinetic studies to determine whether oxamate analogues are selective inhibitors of LDH-C4, owing to their potential usefulness in fertility control and treatment of some cancers. These substances were shown to be competitive inhibitors of LDH isozymes and are able to discriminate among subtle differences that differentiate the active sites of LDH-A4, LDH-B4 and LDH-C4. N-Ethyl oxamate was the most potent inhibitor showing the highest affinity for LDH-C4. However, N-propyl oxamate was the most selective inhibitor showing a high degree of selectivity towards LDH-C4. Non-polar four carbon atoms chains, linear or branched, dramatically diminished the affinity and selectivity towards LDH-C4. N-Propyl oxamate significantly reduced ATP levels, capacitation and mouse sperm motility, in line with results shown by others, suggesting that LDH-C4 plays an essential role in mouse fertility.

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2

Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2.

Hydrogen bond patterns in solid state carboxylic acids. Vibrational behaviour of the catamer pattern as exhibited by the N-alkyloxamic acids

The vibrational study presented in this publication shows that the N-alkyloxamic acids are hydrogen bonded through a catamer hydrogen bond pattern in the solid state. Two different hydrogen bond patterns are possible for these products, and these patterns can be very clearly distinguished by their vibrational behaviour. Deuteration and low temperature spectra make the assignment and characterisation more obvious.