75238-09-4

Usage

Uses

Used in Biochemical Research and Biotechnology:
N-(6-Aminohexyl)maleimide hydrochloride salt is used as a crosslinking reagent for the modification and labeling of proteins, peptides, and other biomolecules. It facilitates the study of protein structure, function, and interactions within biological systems by enabling the formation of stable covalent bonds with thiol groups present in these biomolecules.
Used in Protein Chemistry:
In the field of protein chemistry, N-(6-Aminohexyl)maleimide hydrochloride salt is employed as a valuable tool for the covalent attachment of various functional groups to proteins. This allows researchers to probe the properties and behavior of proteins under different conditions and in various experimental setups.
Used in Analytical Techniques:
N-(6-Aminohexyl)maleimide hydrochloride salt is utilized in various analytical techniques to enhance the detection and quantification of proteins and peptides. Its reactivity with thiol groups allows for the specific labeling of these biomolecules, improving the sensitivity and selectivity of analytical methods.
Used in Drug Development:
In the pharmaceutical industry, N-(6-Aminohexyl)maleimide hydrochloride salt is used in the development of drugs targeting proteins with thiol groups. Its ability to form stable covalent bonds can be leveraged to design drugs with high specificity and potency, potentially leading to more effective treatments for various diseases.
Used in Biosensor Development:
N-(6-Aminohexyl)maleimide hydrochloride salt is employed in the development of biosensors for detecting the presence of thiol-containing biomolecules. Its reactivity with thiol groups enables the creation of highly sensitive and selective biosensors for a wide range of applications, including environmental monitoring, medical diagnostics, and food safety testing.

Upstream product

• 207558-25-6 hexylcarbamic acid tert-butyl ester 
• 4048-33-3 6-amino-1-hexanol 
• 124529-64-2 tert-butyl (6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl)carbamate 

Relevant academic research and scientific papers

Efficient Synthesis of a Family of Bifunctional Chelators Based on the PCTA[12] Macrocycle Suitable for Bioconjugation

PCTA[12] is a 12-membered tetraaza-macrocyclic ligand that incorporates a pyridine unit within the macrocyclic ring and three acetate pendant arms. Unlike DOTA and NOTA chelators, PCTA is a recent entry to the field of macrocyclic polyaminocarboxylate ligands available to complex a variety of M2+/M3+ ions for biomedical applications such as diagnostic and radiotherapeutic. Despite the promising properties of its chelates, only a few of bifunctional chelating agents (BFCAs) derived from PCTA have been described so far. Based on our very recent methodology for the preparation of PCTA[12] itself, we report here the efficient synthesis of several BFCAs derived from PCTA bearing a free reactive function group, mainly devoted to conjugation purposes: ester, carboxylic acid, alcohol, aliphatic amine, aromatic amine, maleimide, bromo or azide functions. These functions were introduced either on the 4-position of the pyridine ring or on the methylene carbon atom of the central acetate chelating arm, while keeping the three carboxylate groups available for metal chelation. Moreover, two of these BFCAs-PCTA were used for conjugation with a tetrapeptide (cholecystokinin analogue), a bioactive molecule (biotin), or a solid support (silica gel).

Novel copolymers and superoxide dismutase modified with said copolymers

Described are copolymers comprising the copolymer--constituting units characterized in the claims and having an average molecular weight of 400 to 20,000. Furthermore superoxide dismutase (SOD) derivatives are described which can be obtained by modification with the above copolymers and have a single chemical structure, retain most of the enzymatic activity of SOD and exhibit a much prolonged plasma half-life. Therefore, they are useful as medicinal chemicals.