75238-77-6

Basic information

• Product Name: 1-BROMO-1,2,3,4-TETRAHYDRONAPHTHALENE
• Synonyms: 1-BROMO-1,2,3,4-TETRAHYDRONAPHTHALENE
• CAS NO: 75238-77-6
• Molecular Formula: C₁₀H₁₁Br
• Molecular Weight: 211.09834
• Mol File: 75238-77-6.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BROMO-1,2,3,4-TETRAHYDRONAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-1,2,3,4-TETRAHYDRONAPHTHALENE(75238-77-6)
• EPA Substance Registry System: 1-BROMO-1,2,3,4-TETRAHYDRONAPHTHALENE(75238-77-6)

Safety Data

• Hazardous Substances Data: 75238-77-6(Hazardous Substances Data)

Usage

General Description

1-Bromo-1,2,3,4-tetrahydronaphthalene is a chemical compound with the molecular formula C10H11Br. It is a brominated derivative of tetrahydronaphthalene, which is commonly used in the synthesis of various pharmaceuticals and agrochemicals. This chemical is primarily used as a building block for the preparation of other organic compounds, and it is also utilized as a solvent in organic reactions. It is important to handle 1-bromo-1,2,3,4-tetrahydronaphthalene with caution, as it is considered hazardous and may cause skin and eye irritation. Additionally, it has the potential to be harmful if inhaled or ingested and can have adverse effects on aquatic ecosystems if released into the environment.

Upstream product

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 447-53-0 1,2-Dihydronaphthalene 
• 119-64-2 tetralin 
• 529-33-9 1,2,3,4-Tetrahydro-1-naphthol 

Downstream Products

• 98074-64-7 1,2,3,4-Tetrahydro-naphth-1-yl-hydrazin 
• 39834-40-7 trans-2-bromo-1,2,3,4-tetrahydronaphthalen-1-ol 
• 447-53-0 1,2-Dihydronaphthalene 
• 75238-72-1 allyl 1-(1,2,3,4-tetrahydro)-naphtyl thioether 

Relevant articles and documents

Development of Novel Phosphino-Oxazoline Ligands and Their Application in Asymmetric Alkynlylation of Benzylic Halides

A new set of stereochemically diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)benzoic acid were developed. Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical coupling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclic α-halides and α-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions. With multi distinct sites for structural modification, a diverse pool of chiral N,N,P-ligands is readily accessed, allowing for rapid optimization of the ligand structure for a specific substrate. Notably, the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic molecules has also been realized for the first time.

BCL-2 INHIBITOR

Disclosed herein is a compound of Formula (I) for inhibiting both Bcl-2 wild type and mutated Bcl-2, in particular, Bcl-2 G101V and D103Y, and a method of using the compound disclosed herein for treating dysregulated apoptotic diseases.

Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles

We herein report a transition-metal-free cross-coupling between secondary alkyl halides/mesylates and aryl/alkenylboronic acid, providing expedited access to a series of nonchiral/chiral coupling products in moderate to good yields. Stereospecific SN2-type coupling is developed for the first time with alkenylboronic acids as pure nucleophiles, offering an attractive alternative to the stereospecific transition-metal-catalyzed C(sp2)-C(sp3) cross-coupling.