75239-13-3

Upstream product

• 75239-12-2 ethyl 5-methyl-1-phenylpyrazole-4-acetate 
• 75239-08-6 ethyl 3-phenylhydrazinomethylene-2,4-dioxovalerate 
• 100-63-0 phenylhydrazine 
• 57432-84-5 ethyl 5-methyl-1-phenylpyrazole-4-glyoxalate 
• 57397-70-3 ethyl 3-(ethoxymethylene)-2,4-dioxovalerate 
• 1082827-43-7 methyl 3-(1-phenyl-1H-pyrazol-5-yl)propanoate 
• 1082827-41-5 methyl (5-methyl-1-phenyl-1H-pyrazol-4-yl)acetate 

Downstream Products

• 1082827-33-5 N-[(2-chloro-4-fluorophenyl)methyl]-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)acetamide trifluoroacetate 

Relevant academic research and scientific papers

PYRAZOLE DERIVATIVES AS P2X7 MODULATORS

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The pyrazole derivatives of formula (I) or salts thereof modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2

Reaction of Ethyl 3-Ethoxymethylene-2,4-dioxovalerate with Monosubstituted Hydrazines

Reactions of ethyl 3-ethoxymethylene-2,4-dioxovalerate (1) with phenyl- and methylhydrazines are described.While the reaction of 1 with phenylhydrazine gave a mixture of ethyl 4-acetyl-1-phenylpyrazole-5-carboxylate (4) and ethyl 5-methyl-1-phenylpyrazole