75251-41-1Relevant academic research and scientific papers
Multicomponent Strecker reaction under high pressure
Matsumoto, Kiyoshi,Kim, Jong Chul,Iida, Hirokazu,Hamana, Hiroshi,Kumamoto, Koji,Kotsuki, Hiyoshizo,Jenner, Gerard
, p. 1734 - 1753 (2007/10/03)
For the first time, uncatalyzed, high-pressure (0.6 GPa) reactions with ketones have proven to be a powerful way to perform the three-component Strecker synthesis of α-amino nitriles in high yields. Two types of double Strecker reactions were achieved, but attempts to perform triple Strecker reactions were unsuccessful.
Azomethines, 1-Azaallyl Anions, and Metastable Secondary Enamines
Knorr, Rudolf,Weiss, Alfons,Loew, Peter,Raepple, Edith
, p. 2462 - 2489 (2007/10/02)
E/Z equilibrium constants of the ketone anils 6a-s do not depend significantly on the inductive substituent effect. 1H NMR chemical shifts used for configurational classification are also effective for assignments in comparable, isomerically almost pure azomethines 6aa-pp and may be explained by the anisotropic shift model.The 1-azaallyl anions 7 prepared by deprotonation are characterized by 1H NMR spectroscopy.Kinetic and thermodynamic control of this metallation reaction result in different preferential configurations of such anions, the methanolysis of which yields metastable sec. enamines 8 by regio- and stereospecific N-protonation.It is possible to estimate further substituent parameters λd from E/Z equilibria.
