75257-54-4Relevant academic research and scientific papers
Antihypertensive (2-Aminoethyl)thiourea Derivatives. 1
Tilley. Jefferson W.,Levitan, Paul,Kierstead, Richard W.,Cohen, Michael
, p. 1387 - 1392 (2007/10/02)
Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas.From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog.In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.
Thiourea derivatives
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, (2008/06/13)
Antihypertensively active thiourea derivatives of the formulas STR1 wherein R, R1, R2, R3 and X are as hereinafter described, as well as a method of using a compound of the formula STR2 wherein R1 ', R2 ', R3 and X are as previously described, or a compound of formula II as an anti-hypertensive agent, is described.
