75272-93-4Relevant academic research and scientific papers
Preparation method of alkyl nitrile compound
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Paragraph 0134-0136, (2020/05/14)
The invention discloses a preparation method of an alkyl nitrile compound shown as formula I. The preparation method comprises the following step: in a solvent, in the presence of an additive, carrying out substitution reaction as shown in the specification on a cyanation reagent and an alkyl halide shown as formula II to obtain the alkyl nitrile compound shown as formula I, wherein the cyanationreagent is Zn (CN) 2 and/or Cu (CN) 2; the additive is one or more of an inorganic base, an organic base and a quaternary ammonium salt.
Copper-catalyzed fragmentation-rearrangement sequence of cycloketoxime esters
Wu, Yixiao,Zhao, Binlin,Shi, Zhuangzhi,Yuan, Yu
supporting information, (2019/12/24)
Copper-catalyzed fragmentation-rearrangement sequence of cycloketoxime esters is reported. This strategy provides direct access to diverse ring-opening acyloxylation nitriles avoiding the use of toxic cyanic reagents with good atom economy and well functi
A Straightforward Conversion of Activated Amides and Haloalkanes into Esters under Transition-Metal-Free Cs 2 CO 3 /DMAP Conditions
Chen, Liuqing,Gu, Ying,Jian, Junsheng,Liu, Yueping,Miao, Liqiong,Wang, Zijia,Zeng, Zhuo
, p. 4078 - 4084 (2019/10/28)
The esterification of activated amides, N -acylsaccharins, under transition-metal-free conditions with good functional group tolerance has been developed, resulting in C-N cleavage leading to efficient synthesis of a variety of esters in moderate to good yields. This work demonstrates that esterification may proceed by using simple N -acylsaccharins, haloalkanes, and Cs 2 CO 3 as oxygen source.
Synthesis of Nitriles from Haloesters, Haloketones and Haloethers
Talekar, D. G.,Joshi, P. L.,Ramaiah, P.,Rao, A. S.
, p. 145 - 151 (2007/10/02)
The action of NaCN on haloesters, haloketones and haloethers has been studied.Haloesters wherein halogen and ester functions are located on adjacent carbon atoms, do not furnish the corresponding nitriles, whereas those with halogen and ester functions not located on adjacent carbon atoms, furnish the corresponding nitriles in good yields.The presence of hydroxy or ether function on the carbon adjacent to primary halide bearing carbon atom does not interfere in the reaction with cyanide. δ-Haloketones are transformed to ketonitriles, γ-Haloketones are transformed to cyclopropyl ketones and epoxyhalides to epoxynitriles.
