75279-39-9

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Acetamino-4-aminopyridine is used as a reagent for the synthesis of pharmaceutical drugs, leveraging its chemical properties to contribute to the development of new medications.
Used in Neurodegenerative Disease Treatment:
In the medical field, 2-Acetamino-4-aminopyridine is used as a potential treatment for neurodegenerative diseases such as multiple sclerosis and spinal cord injury, due to its ability to block potassium channels, which may improve nerve function and muscle strength in affected patients.
Used in Veterinary Medicine Production:
2-Acetamino-4-aminopyridine also finds application in the production of veterinary medicines, indicating its broad utility across different areas of healthcare.
Used as an Intermediate in Organic Synthesis:
Furthermore, it is utilized as an intermediate in the synthesis of organic compounds, highlighting its importance in the chemical industry for creating a variety of products.
Overall, 2-Acetamino-4-aminopyridine has significant potential applications in the development of treatments for neurological disorders and maintains commercial relevance in both the pharmaceutical and chemical industries.

InChI:InChI=1/C7H9N3O/c1-5(11)10-7-4-6(8)2-3-9-7/h2-4H,1H3,(H3,8,9,10,11)

Upstream product

• 179554-64-4 4-azidocarbonyl-2-acetylaminopyridine 
• 13362-28-2 2-aminoisonicotinic acid 
• 54221-95-3 2-(acetylamino)isonicotinic acid 
• 504-29-0 2-aminopyridine 
• 14150-95-9 2-aminopyridine N-oxide 
• 52092-45-2 2-amino-4-nitropyridine N-oxide 
• 4487-48-3 2-acetylamino-4-nitropyridine N-oxide 

Relevant academic research and scientific papers

Synthesis method of 2-amino-4-fluoropyridine

The invention discloses a synthesis method of 2-amino-4-fluoropyridine. The synthesis method comprises the following synthesis steps: 1, taking diaminopyridine as the raw material, carrying out oxidation reaction to prepare 2-aminopyridine N-oxide a; 2, subjecting the compound a to nitration reaction with mixed acid to obtain 2-amino-4-nitropyridine N-oxide b; 3, carrying out acylation reaction onthe compound b and an acylation reagent to obtain 2-acetamino-4-nitropyridine N-oxide c; 4, carrying out reduction reaction on the compound c to obtain 2-acetamino-4-aminopyridine d; 5, carrying outdiazo-reaction on the compound d and HBF4 to obtain diazonium fluoroborate e; and 6, carrying out Balz-Schiemann reaction on the compound e to introduce fluorine atoms and conducting hydrolysis deacetylation to obtain 2-amino 4-fluoropyridine. The method provided by the invention solves the problems of long synthesis route, complicated operation, serious pollution, high cost, low yield and the like in existing synthesis methods.

Development of first lead structures for phosphoinositide 3-kinase-c2γ inhibitors

The importance of complete elucidation of the biological functions of phosphoinositide 3-kinases (PI3K) was realized years ago. They generate 3-phosphoinositides, which are known to function as important second messengers in many inter- and intracellular signaling pathways. However, the functional role of class II PI3Ks is still unclear. Herein, we describe the synthesis of a panel of compounds that were tested against all eight mammalian PI3K-isoforms. We found inhibitors with some selectivity for class II PI3K-C2γ and also compounds with preferred inhibition of class II PI3K-C2β, providing structural leads to develop selective tool compounds.

IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS

The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.

Substituted 2-aminopyridines as inhibitors of nitric oxide synthase

Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders. STR1