52092-45-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-4-nitropyridine-N-oxide is utilized as an intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure and reactivity. It contributes to the development of new drugs by serving as a building block in medicinal chemistry.
Used in Dye Industry:
NANO is employed as a precursor in the production of dyes, leveraging its chemical properties to create a range of colorants used in different applications, such as textiles, plastics, and printing inks.
Used in Explosives and Propellants Industry:
Recognized for its explosive properties, 2-Amino-4-nitropyridine-N-oxide is used in the development of high-energy materials for explosives and propellants, enhancing their performance in military and industrial applications.
Used in Organic Electronics:
NANO has potential applications in the field of organic electronics, where its properties can be harnessed to improve the performance of electronic devices, such as organic light-emitting diodes (OLEDs) and organic solar cells.
Used as a Reagent in Organic Synthesis:
In organic synthesis, 2-Amino-4-nitropyridine-N-oxide serves as a versatile reagent, enabling the synthesis of nitrogen-containing heterocycles and other complex organic molecules for research and industrial purposes.
It is crucial to handle 2-Amino-4-nitropyridine-N-oxide with appropriate safety measures due to its toxic nature and potential to cause harm upon contact with skin and eyes.

InChI:InChI=1/C5H6N3O3/c6-5-3-4(8(10)11)1-2-7(5)9/h1-3,5H,6H2/q+1

Upstream product

• 14432-16-7 2-chloro-4-nitropyridine-N-oxide 
• 109-09-1 2-chloropyridine 
• 14150-95-9 2-aminopyridine N-oxide 
• 504-29-0 2-aminopyridine 
• 2402-95-1 2-chloropyridine-N-oxide 

Downstream Products

• 4487-48-3 2-acetylamino-4-nitropyridine N-oxide 
• 75279-39-9 N-(4-aminopyridin-2-yl)acetamide 
• 4487-50-7 2-amino-4-nitropyridine 

Relevant academic research and scientific papers

Synthesis method of 2-amino-4-fluoropyridine

The invention discloses a synthesis method of 2-amino-4-fluoropyridine. The synthesis method comprises the following synthesis steps: 1, taking diaminopyridine as the raw material, carrying out oxidation reaction to prepare 2-aminopyridine N-oxide a; 2, subjecting the compound a to nitration reaction with mixed acid to obtain 2-amino-4-nitropyridine N-oxide b; 3, carrying out acylation reaction onthe compound b and an acylation reagent to obtain 2-acetamino-4-nitropyridine N-oxide c; 4, carrying out reduction reaction on the compound c to obtain 2-acetamino-4-aminopyridine d; 5, carrying outdiazo-reaction on the compound d and HBF4 to obtain diazonium fluoroborate e; and 6, carrying out Balz-Schiemann reaction on the compound e to introduce fluorine atoms and conducting hydrolysis deacetylation to obtain 2-amino 4-fluoropyridine. The method provided by the invention solves the problems of long synthesis route, complicated operation, serious pollution, high cost, low yield and the like in existing synthesis methods.

Structural and vibrational investigation of 2-amino-4-nitropyridine crystal

The X-ray structure of 2-amino-4-nitropyridine was determined at room temperature. The crystal belongs to the P2(I)/c space group of the monoclinic system (Z = 4, a = 6.7290(10), b = 10.946(2), c = 9.060(2) A, β = 100.03(3) deg) and is built of layers parallel to the (102) crystallographic plane. The molecules in the layer are joined into centrosymmetric dimers by two N-H···N hydrogen bonds (N···N distance = 3.011(3) A), which form rings of C(i) symmetry. The other N-H bonds of the amino groups are involved in N-H···O hydrogen bonds with the oxygen atoms of the nitro groups (N···O distance = 3.054(3) A). These hydrogen bonds join the dimers into an infinite plane. The powder IR and Raman spectra (4000-80 cm-1) were measured for normal and deuterated crystals and are discussed with respect to the crystal structure. The N-H stretching vibrations behave as the stretching vibrations of two almost independent hydrogen bonds. Strong A(g)-A(u)-type splitting is observed for the stretching vibrations of the N-H···N type hydrogen bonds.