75279-53-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-fluorophenylacetonitrile is used as an intermediate for the preparation of RG7388, a potent and selective p53-MDM2 inhibitor. 4-Chloro-2-fluorophenylacetonitrile plays a significant role in the development of cancer therapeutics, as it helps in the synthesis of a drug that targets the p53-MDM2 interaction, which is a critical pathway in tumor suppression and cell cycle regulation.
In addition to its use in the pharmaceutical industry, 4-Chloro-2-fluorophenylacetonitrile may also find applications in other industries, such as:
Used in Chemical Synthesis Industry:
4-Chloro-2-fluorophenylacetonitrile can be used as a building block for the synthesis of various other organic compounds, including dyes, agrochemicals, and specialty chemicals. Its unique molecular structure with a chlorine and fluorine atom on the benzene ring provides a versatile platform for further chemical modifications and functionalization.
Used in Research and Development:
In the field of research and development, 4-Chloro-2-fluorophenylacetonitrile can be employed as a starting material for the exploration of new chemical reactions and the synthesis of novel compounds with potential applications in various fields, such as materials science, medicinal chemistry, and environmental chemistry.
Overall, 4-Chloro-2-fluorophenylacetonitrile is a valuable compound with diverse applications, particularly in the pharmaceutical industry for the development of cancer therapeutics, as well as in chemical synthesis and research and development for the creation of new compounds and materials.

InChI:InChI=1/C8H5ClFN/c9-7-2-1-6(3-4-11)8(10)5-7/h1-2,5H,3H2

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 61072-56-8 4-chloro-2-fluorobenzaldehyde 
• 773837-37-9 sodium cyanide 
• 87417-71-8 4-chloro-1-(chloromethyl)-2-fluorobenzene 

Downstream Products

• 75391-82-1 C₁₉H₁₇ClFN₃ 
• 75391-96-7 6-chloro-1'-methyl-1-(2-nitrophenyl)spiro[indoline-3,4'-piperidine] 
• 75391-88-7 C₁₉H₁₇ClN₄O₂ 
• 75391-89-8 6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro 
• 75391-83-2 6-chloro-1-(2-fluorophenyl)spiro[indoline-3,4'-piperidine] 
• 85422-41-9 1-(2-aminophenyl)-6-chloro-1'-methylspiro(indoline-3,4'-piperidine) 
• 75391-80-9 C₁₉H₂₀ClFN₂ 
• 75391-85-4 6-chloro-1-(2-chlorophenyl)-1'-methylspiro[indoline-3,4'-piperidine] 
• 75391-77-4 C₂₀H₂₀ClF₃N₂ 
• 188424-98-8 ethyl 2-(4-chloro-2-fluorophenyl)acetate 
• 1093097-87-0 C₁₄H₈Cl₂FNO₃ 
• 1093956-69-4 1,1-dimethylethyl 4-(4-chloro-2-fluorophenyl)-4-cyano-1-piperidinecarboxylate 
• 1229705-06-9 4-{[(2R,3S,4R,5S)-4-(4-Chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid 
• 1229705-05-8 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-3-methoxybenzoic acid methyl ester 

Relevant academic research and scientific papers

Rapid and Simple Access to α-(Hetero)arylacetonitriles from Gem-Difluoroalkenes

A scalable cyanation of gem-difluoroalkenes to (hetero)arylacetonitrile derivatives was developed. This strategy features mild reaction conditions, excellent yields, wide substrate scope, and broad functional group tolerance. Significantly, in this reacti

NICOTINAMIDE DERIVATIVES AND THEIR USE AGAINST NEMATODES

Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.

PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES

Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.

Pyrimidin-4-one derivatives, their intermediates for their production and processes for producing these compounds

PCT No. PCT/JP96/02169 Sec. 371 Date Feb. 10, 1998 Sec. 102(e) Date Feb. 10, 1998 PCT Filed Aug. 1, 1996 PCT Pub. No. WO97/06150 PCT Pub. Date Feb. 20, 1997Novel pyrimidin-4-one derivatives of formula [1] are provided, which are useful as active ingredien

ELECTRFLUORATION EN POSITION BENZYLIQUE DANS LE SULFOLANE

The use of sulfolane as a solvent instead of acetonitrile in the electrofluorination of benzylic derivatives 1, (R=H, Cl) gives greater yields of benzylic fluorides 2, since the formation of acetamide byproducts 4 is prevented.However, the parallel fluorination of the aromatic nucleus is not avoided under these conditions.